Abstract：Objective: To observe the changes of β-human chorionic gonadotropin (β-hCG) and tumor necrosis factor-α (TNF-α)/interleukin-10 (IL-10) ratio in patients with gestational diabetes mellitus (GDM), and to analyze the relationship with adverse pregnancy outcomes.Methods: A total of 102 GDM patients admitted to our hospital from January 2020 to January 2023 were included. The serum levels of β-hCG and the TNF-α/IL-10 ratio were detected, and their association with adverse pregnancy outcomes was analyzed.Results: Serum β-hCG and TNF-α/IL-10 ratio of pregnant women with adverse pregnancy outcomes were significantly higher than those of pregnant women with normal pregnancy outcomes (P<0.05). Univariate analysis showed that history of adverse pregnancy, bacterial vaginosis, age and HbA1c were associated with adverse pregnancy outcomes in GDM patients (P<0.05). Logistic regression analysis indicated that adverse pregnancy history, age, HbA1c, β-hCG, and TNF-α/IL-10 ratio were risk factors for adverse pregnancy outcomes in GDM patients (P<0.05). ROC results suggested that the AUCs of serum β-hCG and TNF-α/IL-10 in evaluating adverse pregnancy outcomes in GDM patients were 0.804 (95%CI: 0.695~0.912) and 0.729 (95%CI: 0.614~0.844) respectively. The AUC of the combination of the two indicators was 0.867 (95%CI: 0.787~0.947) in assessing the adverse pregnancy outcomes, and the sensitivity and specificity under the maximum Youden index were 0.786 and 0.811, respectively.Conclusion: Abnormal increases in serum β-hCG and the TNF-α/IL-10 ratio in GDM pregnant women are associated with adverse pregnancy outcomes, and their combined assessment has a high evaluation value for adverse pregnancy outcomes.
2024, Vol. 30 
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