Abstract：Objective: To analyze the correlation neutrophil to lymphocyte ratio (NLR), interleukin-6 (IL-6) and C-reactive protein (CRP) with the prognosis of patients with pooled severe pneumonia (SP) and septic shock (SS). Methods: Ninety- eight patients pooled SP and SS admitted to our hospital from January 2019 to December 2023 were enrolled. The key observation was the correlation of the changes in levels of NLR, IL-6, and CRP with the prognosis of patients. Results: The levels of NLR, IL-6 and CRP in the poor prognosis group were significantly higher than those in the good prognosis group (P<0.05). Pearson correlation analysis revealed that the levels of NLR, IL-6 and CRP were positively correlated with shock index (r=0.412, 0.381, 0.354, P<0.05). Univariate analysis showed that shock index, SOFA score and malnutrition were associated with poor prognosis (P<0.05). Multivariate Logistic regression found that NLR, IL-6, CRP, shock index, SOFA score and malnutrition were risk factors for poor prognosis (P<0.05). ROC analysis showed that the AUCs of NLR, IL-6 and CRP in evaluating the poor prognosis of patients were 0.757, 0.743 and 0.708 respectively. The AUC of NLR+IL-6+CRP was the highest (0.841), and the sensitivity and specificity were 0.774 and 0.836 respectively. The AUC, sensitivity and specificity of combined assessment of NLR, IL-6, CRP, shock index, SOFA score and malnutrition were 0.906, 0.871 and 0.806 respectively.Conclusion: NLR, IL-6 and CRP were abnormally elevated in patients with severe pneumonia combined with septic shock. These three indexes combined with shock index, SOFA score and nutritional status had a high value in evaluating the prognosis of patients.
史梦, 蔡雪芹, 李琼. NLR IL-6 CRP与重症肺炎合并感染性休克患者预后的关系研究[J]. 河北医学, 2024, 30(12): 2054-2059.
SHI Meng, CAI Xueqin, LI Qiong. Correlation between NLR IL-6 CRP with the Prognosis of Patients with Pooled Severe Pneumonia and Septic Shock. HeBei Med, 2024, 30(12): 2054-2059.
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2024, Vol. 30 
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