Abstract：Objective: To analyze the prognostication value of 6 systemic inflammatory indicators, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammatory index (SII), pan-immune inflammatory value (PIV), and systemic inflammatory response index (SIRI), in neonates with intrauterine infectious pneumonia.Methods: A total of 306 high-risk newborns with premature rupture of membranes, prenatal fever of pregnant mothers and gestational diabetes mellitus admitted to our hospital from March 2020 to March 2023 were selected as the study subjects. With etiological examination as the "gold standard", 226 newborns confirmed to be infected with pneumonia were selected as the study group. The control group was 80 non-infectious jaundice neonates. All newborns were given 3mL venous blood immediately after delivery and 6 systemic inflammatory indicators (NLR, PLR, MLR, SII, PIV, SIRI) were detected in time.Results: Compared with the control group, the proportion of premature rupture of membranes, maternal diabetes mellitus and prenatal fever in the study group was higher (P<0.05). Compared with the control group, the levels of NLR, PLR, MLR, SII, PIV and SIRI in the study group were higher (P<0.05). Using the occurrence of intrauterine pneumonia in newborns as the dependent variable (no occurrence=0; occurrence=1), select variables with statistical significance in univariate analysis for multivariate logistics regression analysis, the results showed that premature rupture of membranes, maternal diabetes mellitus, maternal prenatal fever, NLR, PLR, MLR, SII, PIV and SIRI were the influencing factors for the occurrence of intrauterine pneumonia in newborns (P<0.05). ROC curve showed that compared with the single diagnosis of NLR, PLR, MLR, SII, PIV and SIRI, the sensitivity and accuracy of the combined diagnosis of neonatal intrauterine infectious pneumonia were higher (P<0.05).Conclusion: The serum levels of NLR, PLR, MLR, SII, PIV and SIRI of newborns with intrauterine pneumonia were high. The accuracy of the six systemic inflammation indicators in predicting neonatal intrauterine pneumonia was more than 70%, and the combined detection was higher than the single detection in predicting neonatal intrauterine pneumonia.
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2024, Vol. 30 
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