Abstract：Objective: To explore the etiological distribution and high-risk factors of concurrent bacterial infection in hospitalized children with Mycoplasma pneumoniae pneumonia (MPP).Methods: A total of 520 hospitalized children with MPP in the hospital were selected from June 2022 to April 2024 as the research subjects, and they underwent sputum culture pathogen detection. According to the results of automatic microbial identification, the occurrence of concurrent bacterial infection and etiological distribution results of concurrent bacterial infection in these research subjects were recorded. The children with concurrent bacterial infection were set as the infection group, and the other children were set as the non-infection group. Univariate analysis was used to analyze the influencing factors of concurrent bacterial infection in hospitalized children with MPP. Multivariate Logistic regression analysis was adopted to analyze the high-risk factors of concurrent bacterial infection in hospitalized children with MPP.Results: Sputum culture of 520 hospitalized children with MPP showed that 177 cases were positive for bacterial infection and 343 cases were negative, and the incidence of bacterial infection in hospital was 34.04%. 182 strains of pathogenic bacteria were detected in 177 hospitalized MPP children with positive bacterial infection, including 121 strains of Gram-negative bacteria (66.48%) and 61 strains of Gram-positive bacteria (33.52%). Gram-negative bacteria were mainly Klebsiella pneumoniae (33.52%) and Pseudomonas aeruginosa (21.43%), and Gram-negative bacteria were mainly Staphylococcus aureus (25.82%). The proportions of age≤3 years old, malnutrition and fever>1 week, skin rash, C-reactive protein>100 mg/L, respiratory support and hospitalization time>14 days in the infection group were higher compared with those in the non-infection group, and the duration of antibiotic use was longer (P<0.05). Multivariate Logistic regression analysis indicated that age≤3 years old (OR=3.086, 95%CI: 1.497-6.361), duration of antibiotic use (OR=1.104, 95%CI: 1.031-1.182), malnutrition (OR=3.043, 95%CI: 1.697-5.458), fever>1 week (OR=3.068, 95%CI: 1.639-5.774), skin rash (OR=2.735, 95%CI: 1.540-4.856), C-reactive protein>100mg/L (OR=3.105, 95%CI: 1.539-6.263), respiratory support (OR=2.954, 95%CI: 1.726-5.053) and hospitalization time>14 days (OR=2.989, 95%CI: 1.703-5.246) were the high-risk factors leading to concurrent bacterial infection in hospitalized children with MPP (P<0.05).Conclusion: Gram-negative bacteria are the main pathogenic bacteria of concurrent bacterial infection in hospitalized children with MPP, among which Klebsiella pneumoniae and Pseudomonas aeruginosa are at the forefront of infection. There are various high-risk factors for concurrent bacterial infection in hospitalized children with MPP, and targeted measures can be taken to prevent bacterial infection according to these factors.
寿涛, 周碧, 杨林风, 朱峰, 刘祥蕾. 肺炎支原体肺炎住院患儿合并细菌感染的病原学分布及高危因素研究[J]. 河北医学, 2024, 30(11): 1887-1891.
SHOU Tao, ZHOU Bi, YANG Linfeng, et al. Etiological Distribution and High-Risk Factors of Concurrent Bacterial Infection in Hospitalized Children with Mycoplasma Pneumoniae Pneumonia. HeBei Med, 2024, 30(11): 1887-1891.
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2024, Vol. 30 
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