Influence of Three Different Regimens on Tumor Residual Rate of Residual Cavity Edge Objective Remission Rate and Prognosis in Patients with Breast Cancer Undergoing Endoscopic Breast-Conserving Surgery
CUI Yi, XIANG Hui, KE Xianfeng, et al
Shangluo Central Hospital, Shaanxi Shangluo 726000, China
Abstract：Objective: To explore the clinical effect of three different regimens on patients with breast cancer (BC).Methods: Totally 155 patients with BC in the hospital were selected from February 2019 to February 2022, and were divided into three groups by means of different treatment regimens. Patients in group A (n=50) were treated with endoscopic breast-conserving surgery, patients in group B (n=53) received endoscopic breast-conserving surgery + radiofrequency ablation, and patients in group C (n=52) were given endoscopic breast-conserving surgery + radiotherapy. The tumor residual rate of residual cavity edge, clinical efficacy, incidence of complications, quality of life [functional assessment of cancer therapy-breast (FACT-B)] and long-term prognosis were compared among the three groups.Results: There was no statistical significance in the residual tumor rate among group A, group B and group C (16.00% vs 5.66% vs 7.55%, P>0.05). Compared with group A, the objective response rate in group B was higher (83.02% vs 56.00%, P<0.0167), and the objective response rate was statistically different among group A, group B and group C (56.00% vs 83.02% vs 65.38%, P<0.05). There was no statistical difference in the incidence of postoperative complications among group A, group B and group C (16.00% vs 11.32% vs 17.31%, P>0.05). At 3 months after surgery, FACT-B scores in all three groups were enhanced compared with those before surgery (P<0.05), and compared with groups A and C, the increases in group B were greater (P<0.05). After 2 years of follow-up, compared with group A, the local recurrence rate in group C was lower (1.92% vs 16.00%, P<0.0167), but there was no statistical significance in the local recurrence rate between group B and group C (13.21% vs 1.92%, P>0.05), and no statistical significance was shown in the local recurrence rate between group B and group A (13.21% vs 16.00%, P>0.05). The 2-year survival rate revealed no statistical difference among groups A, B and C (88.00% vs 86.79% vs 86.54%, P>0.05).Conclusion: Endoscopic breast-conserving surgery combined with radiofrequency ablation has better clinical efficacy and quality of life, and endoscopic breast-conserving surgery combined with radiotherapy has lower recurrence rate. Both regimens have similar tumor residual rate of residual cavity edge, complications and 2-year survival rate as simple endoscopic breast-conserving surgery.
崔仪, 向辉, 柯贤锋, 李强, 雷珍珍. 三种不同方案治疗对乳腺癌患者腔镜保乳术患者残腔边缘肿瘤残留率客观缓解率及预后的影响[J]. 河北医学, 2024, 30(11): 1881-1886.
CUI Yi, XIANG Hui, KE Xianfeng, et al. Influence of Three Different Regimens on Tumor Residual Rate of Residual Cavity Edge Objective Remission Rate and Prognosis in Patients with Breast Cancer Undergoing Endoscopic Breast-Conserving Surgery. HeBei Med, 2024, 30(11): 1881-1886.
2024, Vol. 30 
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