Abstract：Objective: To study the relationship between serum pro-brain natriuretic peptide (Pro-BNP), electrocardiogram QRS wave duration, and cardiac ultrasound parameters in patients with heart failure (HF).Methods: Totally 104 patients with HF in the hospital were selected from January 2023 to March 2024 as the study subjects, and 30 patients with normal cardiac function during the same period were made the control group. Serum Pro-BNP detection, electrocardiogram examination and echocardiography were performed in both groups. The two groups were compared in terms of serum Pro-BNP level, QRS wave duration and cardiac ultrasound parameters [left ventricular ejection fraction (LVEF), LVEDV and LVESV]. According to the cardiac function evaluation status and prognosis status, patients with HF were divided into grade I-II group, grade III-IV group, good prognosis group, and poor prognosis group. Serum Pro-BNP level, QRS wave duration and cardiac ultrasound parameters were compared between grade I-II group and grade III-IV group and between good prognosis group and poor prognosis group. Pearson correlation analysis was performed on the relationship between these indicators in patients with HF.Results: Serum Pro-BNP level, QRS wave duration, LVEDV and LVESV in the heart failure group were higher (P<0.05) while LVEF was lower than in the control group (P<0.05). Serum Pro-BNP level, QRS wave duration, LVEDV and LVESV in cardiac function grade III-IV group were higher (P<0.05) while LVEF was lower compared to grade I-II group (P<0.05). The level of serum Pro-BNP, QRS wave duration, LVEDV and LVESV in the poor prognosis group were higher than in the good prognosis group (P<0.05) while the LVEF was lower (P<0.05). Serum Pro-BNP level in patients with HF was positively correlated with QRS wave duration, LVEDV and LVESV (P<0.05), and was negatively correlated with LVEF (P<0.05). QRS wave duration was positively associated with LVEDV and LVESV (P<0.05), and inversely related to LVEF (P<0.05).Conclusion: There is a significant correlation between serum Pro-BNP level, electrocardiogram QRS wave duration and cardiac ultrasound parameters in patients with heart failure, and the above indicators are associated with the disease condition and prognosis of patients.
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2024, Vol. 30 
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