Abstract：Objective: To explore and analyze the association between changes of neutrophil (NE) and coagulation parameters and lower extremity deep venous thrombosis (DVT) in patients after craniocerebral trauma surgery.Methods: A total of 105 patients with craniocerebral trauma in the hospital were enrolled from April 2021 to April 2024. The changes of NE, four coagulation indexes and D-dimer (D-D) were measured after surgery. Logistic regression analysis was used to analyze the related factors affecting the occurrence of lower extremity DVT, and receiver operating characteristic curve (ROC) was drawn to evaluate the predictive efficiency of NE and coagulation parameters on lower extremity DVT.Results: The thrombin time (TT), prothrombin time (PT) and activated partial prothrombin time (APTT) of lower extremity DVT patients after craniocerebral trauma surgery were significantly shorter than those of non-DVT patients (P<0.05), and the levels of NE, fibrinogen (FIB) and D-D were significantly higher (P<0.05). The proportion of tracheotomy in DVT patients was higher than that in non-DVT patients, and the surgical time was longer than that in non-DVT patients (P<0.05). Logistic regression analysis suggested that tracheotomy, surgical time, NE, PT, FIB and D-D were the risk factors affecting postoperative lower extremity DVT (P<0.05). ROC curve indicated that the AUCs of NE, PT, FIB and D-D in evaluating lower extremity DVT were 0.787, 0.769, 0.707 and 0.779 respectively. The AUC of the combination of the four indexes in assessing lower extremity DVT was 0.958, and the sensitivity and specificity under the maximum Youden index were 0.962 and 0.899 respectively.Conclusion: The abnormal changes of coagulation parameters such as NE, PT, FIB and D-D in patients after craniocerebral trauma surgery are related to the risk of lower extremity DVT, and the combination of NE, PT, FIB and D-D has high predictive value on lower extremity DVT.
2024, Vol. 30 
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