Effect of Polyene Phosphatidylcholine Injection Combined with Adenosylmethionine Butanedisulfonate on Liver Function, Albumin, and Coagulation Indicators in Patients with Liver Failure
YE Chong, WU Qianqian, LIU Changwei, et al
The First Affiliated Hospital of Anhui Medical University, Anhui Hefei 230022, China
Abstract：Objective: To investigate the effects of polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate on liver function, albumin, and coagulation indicators in patients with liver failure. Methods: A total of 107 patients with liver failure treated at The First Affiliated Hospital of Anhui Medical University from December 2021 to December 2023 were selected and randomly divided into a control group (n=53, treated with polyene phosphatidylcholine injection) and a combined group (n=54, treated with polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate). The therapeutic effects, liver function, protein-related indicators, coagulation function, and complications of liver failure were compared between the two groups. Results: The total effective rate in the combined group (94.44%) was higher than in the control group (81.13%), with a statistically significant difference (P<0.05). After 4 weeks of treatment, the differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) levels before and after treatment were greater in the combined group [(204.07±22.85) U/L, (151.45±30.16) U/L, (212.10±26.64) μmoL/L] compared to the control group [(189.23±24.70) U/L, (123.03±29.48) U/L, (196.59±23.20) μmoL/L], with statistical significance (P<0.05). The combined group also showed significantly higher improvements in serum total protein (TP), albumin (ALB), and prealbumin (PA) levels [(7.41±2.26) g/L, (8.53±2.08) g/L, (55.24±10.72) mg/L] compared to the control group [(2.64±1.69) g/L, (4.56±1.75) g/L, (36.18±11.82) mg/L] (P<0.05). Additionally, fibrinogen (FIB), prothrombin activity (PTA), and D-dimer (D-D) improvements in the combined group [(0.55±0.17) g/L, (24.89±3.92)%, (1.21±0.44) mg/L] were greater than those in the control group [(0.34±0.20) g/L, (18.33±4.06)%, (1.02±0.35) mg/L] (P<0.05). The incidence of complications of liver failure was not significantly different between the two groups (P>0.05). Conclusion: The combination of polyene phosphatidylcholine injection and adenosylmethionine butanedisulfonate improves liver and coagulation function in patients with liver failure. The combined treatment is more effective than monotherapy.
叶翀, 吴倩倩, 刘昌伟, 刘婷婷. 多烯磷脂酰胆碱注射液联合丁二磺酸腺苷蛋氨酸液对肝衰竭患者肝功能白蛋白及凝血指标的影响[J]. 河北医学, 2024, 30(10): 1727-1732.
YE Chong, WU Qianqian, LIU Changwei, et al. Effect of Polyene Phosphatidylcholine Injection Combined with Adenosylmethionine Butanedisulfonate on Liver Function, Albumin, and Coagulation Indicators in Patients with Liver Failure. HeBei Med, 2024, 30(10): 1727-1732.
2024, Vol. 30 
冀公网安备13080202000677号