Abstract：Objective: To investigate the relationship of neutrophil (NEU)/albumin (ALB), hemodynamics and immunoglobulins levels with renal function outcome in elderly patients with infection-induced acute kidney injury (AKI). Methods: Totally 117 elderly patients with infection-induced AKI in the hospital were selected from January 2021 to December 2023 as the research subjects. NEU, ALB, hemodynamics and immunoglobulin were detected at admission. The patients were treated with comprehensive symptomatic treatment and were divided into good outcome group and poor outcome group according to the outcome of renal function. The levels of NEU/ALB, hemodynamics and immunoglobulins were compared between groups. Multivariate Logistic regression analysis was used to analyze the influencing factors of renal function outcome in elderly patients with infection-induced AKI. Results: There were no statistical differences in gender, age, body mass index (BMI) and urinary protein between the good outcome group and the poor outcome group (P>0.05), but serum creatinine level was lower than that in the poor outcome group (P<0.05). NEU and NEU/ALB in the good outcome group were lower than those in the poor outcome group (P<0.05) while ALB, IgG and IgM levels were higher (P<0.05), and MAP and CI were higher than those in the poor outcome group (P<0.05), but the HR and IgA were not statistically different compared with those in the poor outcome group (P>0.05). Multivariate Logistic regression analysis showed that NEU/ALB, MAP, CI and IgG were influencing factors of renal function outcome in elderly patients with infection-induced AKI (P<0.05). Conclusion: The NEU/ALB, hemodynamics and immunoglobulins levels are correlated with renal function outcome in elderly patients with infection-induced acute kidney injury. The detection of the above indicators is helpful to evaluate the renal function outcome of patients.
谢娟, 倪刚, 潘亚超, 王羊洋. 感染所致急性肾损伤老年患者NEU/ALB血流动力学免疫球蛋白水平与肾功能转归的关系研究[J]. 河北医学, 2024, 30(10): 1722-1726.
XIE Juan, NI Gang, PAN Yachao, et al. Relationship between NEU/ALB Hemodynamics, Immunoglobulins and Renal Function Outcome in Elderly Patients with Infection-Induced Acute Kidney Injury. HeBei Med, 2024, 30(10): 1722-1726.
[1] Kellum J A,Artigas A,Gunnerson K J,et al.Use of biomarkers to identify acute kidney injury to help detect sepsis in patients with infection[J].Critical Care Medicine,2021,49(4):360-368. [2] 苟丽霞,刘朝朝,陈娜.动态监测血浆SOD,CysC,KIM1水平对老年脓毒症患者发生急性肾损伤风险的预测价值[J].武汉大学学报(医学版),2024,45(4):442-445,450. [3] 郭茂松,王群文,尹路.肾脏血流动力学超声监测对急性肾损伤的预测价值[J].临床急诊杂志,2023,24(9):454. [4] 李白翎,孙丽君,孙海鹏.KDIGO指南中急性肾损伤诊断标准对心脏外科术后患者预后的预测能力强于RIFLE和AKIN标准[J].中国循环杂志,2016,31(z1):83. [5] Khongkhanin U,Intarakul N,Durongbhandhu T,et al.Risk factors and a prediction score were evaluated for early detection of acute kidney injury caused by dengue viral infection in children[J].Pediatric nephrology: journal of the International Pediatric Nephrology Association,2023,38(7):2428-2429. [6] Garg B,Mehta H M,Wang B,et al.Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation,without eliciting an unfolded protein response[J].Journal of Biological Chemistry,2020,295(21):7492-7500. [7] 张巍,邵明亮,苗同国,等.慢性乙型肝炎病毒感染合并急性肾损伤的发病特点及近期预后分析[J].中国现代医学杂志,2020,30(1):70-76. [8] Jocher B,Nakajima T,Tanaka Y,et al.Incidence and risk factors for acute kidney injury post-heart transplant: an analysis of peri-operative hemodynamics[J].The Journal of Heart and Lung Transplantation,2020,39(4):290. [9] Lu L,Feng Y,Liu Y,et al.The systemic immune-inflammation index may be a novel and strong marker for the accurate early prediction of acute kidney injury in severe acute pancreatitis patients[J].Journal of investigative surgery : the official journal of the Academy of Surgical Research,2021,35(5):962-966. [10] 窦晓婧,王清平,翁亦齐,等.肝移植患儿术中血流动力学变化与急性肾损伤的相关性[J].临床麻醉学杂志,2021,37(4):343-347.
2024, Vol. 30 
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