Abstract：Objective: To explore the diagnostic value of multi-slice spiral CT combined with serum cholinesterase (ChE), α-hydroxybutyrate dehydrogenase (α-HBDH), and progranulin (PGRN) in the diagnosis of pulmonary tuberculosis combined with lung cancer. Methods: From June 2021 to June 2023, 84 patients with pulmonary tuberculosis accepted by our hospital were collected. Among them, 36 patients diagnosed with pulmonary tuberculosis combined with lung cancer through pathological examination were made the test group, and 48 patients with simple pulmonary tuberculosis were made the control group. All patients underwent multi-slice spiral CT examination. Enzyme-linked immunosorbent assay (ELISA) was applied to detect the expression levels of ChE, α-HBDH, and PGRN in serum. ROC curve was applied to analyze the diagnostic value of multi-slice spiral CT combined with serum ChE, α-HBDH, and PGRN for pulmonary tuberculosis combined with lung cancer. Results: The proportions of masses, pleural indentation sign, lobulation sign, pleural effusion, spiculation, and nodular shadow sign in the test group were higher than those in the control group (P<0.05). Compared with the control group, the serum ChE level in the test group was reduced, while α-HBDH and PGRN levels were increased (P<0.05). Compared with individual diagnosis, the combination of multi-slice spiral CT and serum ChE, α-HBDH, and PGRN had a higher AUC in the diagnosis of pulmonary tuberculosis combined with lung cancer (z=3.497, P=0.001; z=4.310, P<0.001; z=3.328, P=0.001; z=4.518, P<0.001). Conclusion: Serum ChE expression is low, and the α-HBDH and PGRN expression is high in patients with pulmonary tuberculosis combined with lung cancer. Multi-slice spiral CT combined with serum ChE, α-HBDH, and PGRN has a high diagnostic value for pulmonary tuberculosis combined with lung cancer.
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2024, Vol. 30 
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