Effectiveness of Roxithromycin Combined with Mometasone Furoate Nasal Spray in the Treatment of Bronchial Asthma and Its Effect on Inflammatory Factors and Immune Functions
FU Ling, WANG li, ZENG Xiaojie, et al
General Hospital of Western Theater Command, Sichuan Chengdu 610083, China
Abstract：Objective: To explore the effects of roxithromycin combined with mometasone furoate nasal spray on serum inflammatory factors and immune function in children with bronchial asthma.Methods: A total of 120 children with bronchial asthma diagnosed in the hospital from June 2020 to June 2023 were completely randomized by random number table method into control group and experimental group, the control group was treated with mometasone furoate nasal spray, and the experimental group was treated with roxithromycin combined with mometasone furoate nasal spray for 4 weeks. Lung function, T-cell subpopulation levels, serum inflammatory factors, asthma control test (ACT) scores, quality of life, and adverse effects were compared between the two groups.Results: After treatment, peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), and FEV1/forced vital capacity (FVC) were increased in both groups, and changes in amplitude of the above indexes were greater in the experimental group (P<0.05). After treatment, CD3+, CD4+ and CD4+/CD8+ were increased, while CD8+ was decreased in both groups, and changes amplitude of the above indexes was greater in experimental group (P<0.05). After treatment, levels of serum interleukin (IL)-8, IL-13, and tumor necrosis factor-α (TNF-α) were decreased, while levels of serum γ-interferon (IFN-γ), scores of ACT and quality of life were increased in both groups and changes the amplitude of the above indexes was greater in the experimental group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion: Roxithromycin combined with mometasone furoate nasal spray can improve pulmonary function, asthma control, and immune function, regulate the inflammatory response, and improve quality of life in children with bronchial asthma, which has good safety.
伏伶, 王丽, 曾晓洁, 邹燕, 王君霞. 罗红霉素联合糠酸莫米松鼻喷剂治疗支气管哮喘的效果及对炎症因子免疫功能的影响[J]. 河北医学, 2024, 30(9): 1567-1571.
FU Ling, WANG li, ZENG Xiaojie, et al. Effectiveness of Roxithromycin Combined with Mometasone Furoate Nasal Spray in the Treatment of Bronchial Asthma and Its Effect on Inflammatory Factors and Immune Functions. HeBei Med, 2024, 30(9): 1567-1571.
[1] Jones LM,Regan C,Wolf K,et al.Effect of osteopathic manipulative treatment on pulmonary function testing in children with asthma[J].Osteopath Med,2021,121(6):589-596. [2] Dragonieri S,Quaranta VN,Scisci E,et al.The role of education in the self-compilation of asthma control test score in patients with asthma[J].Acta Biomed,2022,93(3):e2022177. [3] 常彩虹,吴河山,高玉林,等.小青龙汤联合信必可都保治疗支气管哮喘的临床疗效及对炎症因子、气道重塑和免疫功能的影响[J].中药材,2021,44(5):1249-1253. [4] 吕晓龙,蔺静静.罗红霉素辅助治疗支气管哮喘有效性的Meta分析[J].中国医药导报,2016,13(27):179-183. [5] Ohnishi H,Otani T,Kanemitsu Y,et al.A systematic review and meta-analysis of macrolides in the management of adult patients with asthma[J].Allergol Int,2024,73(3):382-389. [6] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181. [7] Ghimire JJ,Jat KR,Sankar J,et al.Azithromycin for poorly controlled asthma in children:a randomized controlled trial[J].Chest,2022,161(6):1456-1464. [8] Chu F,Liang L,Chen F.Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma[J].Allergol Immunopathol (Madr),2023,51(4):151-157. [9] Baker A,Grobler A,Davies K,et al.Effectiveness of intranasal mometasone furoate vs saline for sleep-disordered breathing in children:a randomized clinical trial[J].JAMA Pediatr,2023,177(3):240-247. [10] Sagara H,D'Andrea P,Tanase AM,et al.Long-term safety of once-daily indacaterol acetate/glycopyrronium bromide/mometasone furoate high-dose,and indacaterol acetate/mometasone furoate high-dose,in Japanese patients with inadequately controlled asthma:Results from two open-label,52-week studies[J].Asthma,2023,60(2):403-411. [11] Song Y,Pan K,Chen Y,et al.The efficacy of mometasone furoate for children with asthma:a meta-analysis of randomized controlled trials[J].Postepy Dermatol Alergol,2021,38(5):740-745. [12] Chowers M,Gerassy-Vainberg S,Cohen-Poradosu R,et al.The effect of macrolides on mortality in bacteremic pneumococcal pneumonia:a retrospective,nationwide cohort Study,Israel,2009-2017[J].Clin Infect Dis,2022,75(12):2219-2224. [13] 陈芳.小剂量罗红霉素对支气管哮喘患儿细胞免疫功能及炎症因子水平的影响[J].新乡医学院学报,2020,37(1):68-71. [14] Luo YL,Li YF,Zhu YP,et al.Effects of human umbilical cord blood mononuclear cells on ovalbumin-induced asthma in mice[J].Thorac Dis,2023,15(10):5454-5465. [15] 李青,梁宽,胡梦娇,等.小剂量红霉素联合孟鲁司特钠治疗儿童难治性哮喘对血清炎症因子及C-ACT评分的影响[J].海南医学,2023,34(4):529-533. [16] Toki S,Goleniewska K,Zhang J,et al.TSLP and IL-33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type-2 airway inflammation[J].Allergy,2020,75(7):1606-1617. [17] 李莎,舒秀兰.小儿肺热咳喘颗粒联合丙酸氟替卡松治疗小儿支气管哮喘疗效及对IL-6、IL-8及TNF-α水平的影响[J].中华中医药学刊,2021,39(3):237-240. [18] 陈慧君,顾晓菲,田江华,等.罗红霉素对中性粒细胞哮喘大鼠气道炎症、气道重塑和钙结合蛋白S100A9表达的影响[J].现代实用医学,2021,33(6):713-715,封2. [19] 顾晓菲,陈慧君,陈鑫淼,等.RAGE在哮喘大鼠中的表达及罗红霉素的干预作用[J].中华医学杂志,2019,99(32):2542-2546.
2024, Vol. 30 
冀公网安备13080202000677号