Abstract：Objective: To analyze the influencing factors of contrast agent reflux in infertile women during transvaginal real-time three-dimensional hysterosalpingo-contrast sonography (RT-3D-HyCoSy), and to provide a reference for the prevention and treatment of contrast agent reflux.Methods: The case data of 125 patients of infertility who received RT-3D-HyCoSy examination in the hospital were collected from January 2022 to September 2023. According to whether contrast agent reflux occurred, they were divided into the contrast agent reflux group (n=21) and the contrast agent non-reflux group (n=104). Univariate analysis and multivariate Logistic regression analysis were used to analyze the risk factors of contrast agent reflux during RT-3D-HyCoSy.Results: The proportions of patients with secondary infertility, history of intrauterine surgery, adenomyosis, history of ectopic pregnancy, adnexal mass, uterine deformity, moderate-to-severe contrast agent injection pressure, endometrial thickness≤3.5 mm, tube obstruction, and angiography time ≤5 days after menstruation were higher in contrast agent reflux group than those in contrast agent non-reflux group (all P<0.05). Secondary infertility (OR=2.088, 95%CI=1.119~3.893, P=0.021), history of ectopic pregnancy (OR=2.061, 95%CI=1.136~3.739, P=0.018), endometrial thickness≤3.5 mm (OR=2.319, 95%CI=1.186~4.533, P=0.014) and tube obstruction (OR=2.109, 95%CI=1.259~3.531, P=0.005) were the risk factors of contrast agent reflux in infertility women during RT-3D-HyCoSy (P<0.05).Conclusion: Secondary infertility, history of ectopic pregnancy, endometrial thickness≤3.5 mm, and tube obstruction are risk factors of contrast agent reflux in women with infertility during RT-3D-HyCoSy examination. It is necessary to pay clinical attention to the prevention of contrast agent reflux during RT-3D-HyCoSy examination in infertile women using the above risk factors.
李冰, 陈晓艺, 林欣, 王金萍, 张靖. 125例不孕症RT-3D-HyCoSy时发生造影剂逆流的影响因素分析[J]. 河北医学, 2024, 30(9): 1560-1566.
LI Bing, CHEN Xiaoyi, LIN Xin, et al. Analysis of Factors Influencing the Occurrence of Contrast Reflux during RT-3D-HyCoSy in 125 Cases of Infertility. HeBei Med, 2024, 30(9): 1560-1566.
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2024, Vol. 30 
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