Study on Relationship between Synovial Fluid Oxidative Stress Indexes and MMPs Indexes and Pain Degree and Foot-Ankle Function in Patients with Ankle Trauma
DONG Jianbin, et al
The First Hospital of Yulin, Shaanxi Yulin 719000, China
Abstract：Objective: To observe the changes of oxidative stress indexes and matrix metalloproteinases (MMPs) levels in synovial fluid of patients with ankle trauma, and to analyze their association with pain degree and foot-ankle function.Methods: A total of 163 patients with ankle trauma admitted from February 2020 to February 2023 were enrolled. The levels of oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA)], MMP-3 and MMP-13 in synovial fluid were measured, and the relationship between their levels and pain degree and foot-ankle function was analyzed.Results: There were statistical differences in the levels of SOD, MDA, MMP-3 and MMP-13 in synovial fluid among patients with different pain degrees (P<0.05). The level of SOD in the pain-free group was higher than that in the mild group and the moderate group (P<0.05) while the levels of MDA, MMP-3 and MMP-13 were significantly lower than those in the mild and moderate groups (P<0.05). The level of SOD in the mild group was higher than that in the moderate group (P<0.05), while the levels of MDA, MMP-3 and MMP-13 were significantly lower than those in the moderate group (P<0.05). The levels of SOD, MDA, MMP-3 and MMP-13 in the synovial fluid of patients with different ankle functions were statistically different (P<0.05). The level of SOD in the excellent group was higher than that in the good group, the fair group and the poor group (P<0.05), while the levels of MDA, MMP-3 and MMP-13 were significantly lower than those in the good group, the fair group and the poor group (P<0.05). The level of SOD in the good group was higher (P<0.05) ,while the levels of MDA, MMP-3 and MMP-13 were significantly lower than those in the fair group and the poor group (P<0.05). The level of SOD in the fair group was higher than that in the poor group (P<0.05) while the levels of MDA, MMP-3 and MMP-13 were significantly lower (P<0.05). Spearman correlation analysis showed that SOD was negatively correlated with ankle pain degree (r=-0.546, P<0.05), and MDA, MMP-3 and MMP-13 were positively correlated with degree of ankle pain (r=0.559, 0.595, 0.517, P<0.05). SOD was positively correlated with ankle function (r=0.495, P<0.05). MDA, MMP-3 and MMP-13 were negatively correlated with ankle function (r=-0.571, -0.574, -0.532, P<0.05). ROC curve revealed that the AUC of the combination of the four indexes of SOD, MDA, MMP-3 and MMP-13 in evaluating the excellent and good rate of ankle function was 0.955, which was significantly higher than the AUC of each single index (P<0.05), and the sensitivity and specificity were 0.835 and 0.944 respectively. Conclusion: There are differences in the levels of SOD, MDA, MMP-3 and MMP-13 in the synovial fluid of ankle trauma patients with different pain degrees and ankle functions, and the above indexes are meaningful to effectively evaluate the recovery of foot-ankle function.
董建彬, 白顺宁, 陈强. 关节液氧化应激指标及MMPs指标与踝关节创伤患者疼痛程度及足踝功能的关系研究[J]. 河北医学, 2024, 30(9): 1550-1554.
DONG Jianbin, et al. Study on Relationship between Synovial Fluid Oxidative Stress Indexes and MMPs Indexes and Pain Degree and Foot-Ankle Function in Patients with Ankle Trauma. HeBei Med, 2024, 30(9): 1550-1554.
[1] Moseley M,Rivera-Diaz Z,Fein DM.Ankle injuries[J].Pediatr Rev,2022,43(3):185-187. [2] Weinraub GM,Vijayakumar A.Arthroscopy for traumatic ankle injuries[J].Clin Podiatr Med Surg,2023,40(3):529-537. [3] 韩广弢,李皓桓,蔡伟松,等.骨关节炎中的氧化应激信号通路研究进展[J].中国医药导报,2020,17(9):29-32. [4] Jansen H,Jordan M,Frey S,et al.Active controlled motion in early rehabilitation improves outcome after ankle fractures: a randomized controlled trial[J].Clin Rehabil,2018,32(3):312-318. [5] Polzer H,Rammelt S.Fractures of the ankle joint[J].Unfallchirurg,2021,124(3):173-174. [6] 范峥睿,马剑雄,王颖,等.踝关节创伤性关节炎的治疗现状及其相关进展[J].中华创伤骨科杂志,2020,22(4):360-364. [7] 刘广宇,徐西林,李志刚,等.平衡针联合骨折挫伤胶囊治疗急性踝关节扭伤临床观察[J].中国中医急症,2023,32(10):1774-1778. [8] 贺军,林炎水.微创治疗创伤性肘关节僵硬及对肘关节功能、血清学指标的影响[J].实用医院临床杂志,2021,18(1):52-56. [9] Gains CC,Giannapoulos A,Zamboulis DE,et al.Development and application of a novel in vivo overload model of the Achilles tendon in rat[J].Biomech,2023(151):111546. [10] 姜万嵩,韩庚奋,刘成,等.踝关节骨折后创伤性骨性关节炎患者外周血IL-1β和MMP-13水平及其与关节功能的相关性研究[J].现代检验医学杂志,2022,37(5):171-175. [11] 韦中阳,桑敬伟,李国有.关节液血管活性肠肽水平、白细胞介素-1β、基质金属蛋白酶3与踝创伤性关节炎症状严重程度、足踝功能的相关性分析[J].安徽医药,2021,25(5):983-987.
2024, Vol. 30 
冀公网安备13080202000677号