Correlation between Serum Mir-647 Levels and In-Stent Restenosis after Bare Metal Stent Placement in Patients with Lower Limb Atherosclerotic Occlusive Disease
ZHANG Chao, ZHANG Xiaojing, YANG Xiaojun, et al
Linfen People's Hospital, Shanxi Linfen 041099, China
Abstract：Objective: To explore and analyze the association between serum short non-coding RNA-647 (miR-647) level and in-stent restenosis (ISR) in patients with lower extremity arteriosclerosis obliterans (ASO) after bare metal stent implantation.Methods: Totally 182 patients with lower extremity ASO in the hospital were enrolled from September 2020 to September 2023. Serum miR-647 level after bare metal stent implantation was detected, and the correlation between its level change and ISR was analyzed.Results: Out of 182 ASO patients, 43 experienced ISR after metal bare stent implantation, with an incidence rate of 23.63%. The levels of miR-647, neutrophil to lymphocyte ratio (NLR), and C-reactive protein (CRP) in ISR patients were significantly higher than those in non-ISR patients, with statistical significance (P<0.05). Univariate analysis showed statistical differences in Fontaine staging, age, hypertension, and diabetes mellitus between ASO patients with postoperative ISR and patients without ISR (P<0.05). Person correlation analysis showed that miR-647 was positively correlated with NLR and CRP levels (r=0.351, 0.402, P<0.05). Logistic regression analysis showed that Fontaine staging, age, miR-647, NLR, CRP level, hypertension, and diabetes mellitus were risk factors for postoperative ISR in ASO patients (P<0.05). Concerning the ROC curve, the area under the curve (AUC), optimal cut-off value, sensitivity, and specificity of miR-647 expression level in evaluating postoperative ISR were 0.767 (95%CI:0.676-0.858), 0.980, 0.581 and 0.899 respectively.Conclusion: Serum miR-647 expression in patients with ASO after bare metal stent implantation is related to the occurrence of ISR, and has certain predictive and evaluated value on the occurrence of ISR.
张超, 张小晶, 杨小军, 梁萧, 林友杰. 下肢动脉硬化闭塞症患者金属裸支架置入术后血清miR-647水平与支架内再狭窄相关性研究[J]. 河北医学, 2024, 30(9): 1534-1538.
ZHANG Chao, ZHANG Xiaojing, YANG Xiaojun, et al. Correlation between Serum Mir-647 Levels and In-Stent Restenosis after Bare Metal Stent Placement in Patients with Lower Limb Atherosclerotic Occlusive Disease. HeBei Med, 2024, 30(9): 1534-1538.
2024, Vol. 30 
冀公网安备13080202000677号