Abstract：Objective: To analyze the predictive value of blood urea nitrogen (BUN), serum creatinine (SCr), and cystatin C (CysC) for acute kidney injury (AKI) in asphyxiated full-term neonates.Methods: The clinical data of 85 asphyxiated full-term neonates born in the hospital from January 2020 to June 2023 were collected retrospectively. According to the presence or absence of AKI, neonates selected were divided into the AKI group (n=30) and the non-AKI group (n=55). The clinical data, BUN, SCr, and CysC of the two groups were compared. Multivariate logistic regression analysis was performed to identify the risk factors for AKI in asphyxiated full-term neonates. The receiver operating characteristic (ROC) curves were used to analyze the predictive value of BUN, SCr, and CysC for AKI in asphyxiated full-term neonates.Results: There was no statistically significant difference in gender, gestational age, birth weight, delivery mode, or number of births between the two groups (P>0.05). The proportion of severe asphyxia and the levels of BUN, SCr, and CysC in the AKI group were higher than those in the non-AKI group (P<0.05). Logistic regression analysis found that severe asphyxia and abnormally elevated levels of BUN, SCr and CysC were independent factors in predicting the development of AKI in term neonates with asphyxia (P<0.05). ROC curves indicated that BUN, SCr, and CysC had certain predictive values for AKI in asphyxiated full-term neonates. Among them, the area under the curve (AUC) and sensitivity of CysC were higher than those of BUN and SCr (P<0.05).Conclusion: BUN, SCr, and CysC level tests are of relevance in guiding the development of AKI in full-term asphyxiated neonates, and serum CysC has the best guiding value.
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2024, Vol. 30 
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