Abstract：Objective: To explore the application effectiveness of recombinant bovine basic fibroblast growth factor (bFGF) combined with ultrasonic bone scalpel in the removal of impacted mandibular teeth.Methods: A total of 105 patients with impacted mandibular teeth treated at our hospital from October 2020 to October 2023 were randomly divided into a control group (n=52) and an observation group (n=53) using simple random grouping. The control group underwent bFGF combined with conventional rotary drilling for extraction, while the observation group underwent bFGF combined with ultrasonic bone scalpel for extraction. Surgical-related indicators, clinical treatment outcomes, postoperative swelling, restricted mouth opening recovery, expression levels of inflammatory factors [tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule 1 (ICAM1), myeloperoxidase (MPO)] in gingival crevicular fluid, and dry socket occurrence were compared between the two groups.Results: The operation time and intraoperative blood loss in the observation group were significantly lower than those in the control group (P<0.05). Before and after surgery, the improvement in systolic blood pressure, diastolic blood pressure, and blood glucose levels in the observation group was lower than that in the control group (P<0.05). The excellent and good treatment rate in the observation group was 98.11%, which was higher than 82.69% in the control group (P<0.05). Postoperative swelling and incidence of restricted mouth opening were lower in the observation group compared to the control group (P<0.05). The increase in TNF-α, ICAM1, and MPO levels in the gingival crevicular fluid was lower in the observation group than in the control group (P<0.05). The total incidence of complications in the observation group was lower than that in the control group (P<0.05).Conclusion: bFGF combined with ultrasonic bone scalpel for the treatment of impacted mandibular teeth is effective, improves inflammatory responses in gingival crevicular fluid, and reduces the risk of complications.
魏恩典, 伏晓, 游景秀. bFGF联合超声骨刀在下颌阻生牙拔除中的应用研究[J]. 河北医学, 2024, 30(8): 1349-1353.
WEI Endian, FU Xiao, YOU Jingxiu. Application Study of bFGF Combined with Ultrasonic Bone Scalpel in Removal of Impacted Mandibular Teeth. HeBei Med, 2024, 30(8): 1349-1353.
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2024, Vol. 30 
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