Clinical Efficacy of Compound Betamethasone Combined with Iliac Fascia Block in Postoperative Analgesia for Patients Undergoing Total Hip Arthroplasty: Effects on TLR4/NF-κB Signaling Pathway
WANG Kexin, LIU Zhong, WANG Mengnan, et al
Chengde Central Hospital, Hebei Chengde 067000, China
Abstract：Objective: To explore the clinical value of compound betamethasone combined with iliac fascia block in postoperative analgesia for patients undergoing total hip arthroplasty (THA), and its influence on the TLR4/NF-κB signaling pathway. Methods: A total of 152 patients undergoing THA from November 2022 to December 2023 were included in this study. Patients were randomly divided into two groups: the control group received iliac fascia block, and the experimental group received compound betamethasone and iliac fascia block. Parameters compared between the two groups included perioperative indicators, pain scores, hip joint mobility, TLR4/NF-κB signaling pathway factors, and incidence of adverse reactions. Results: There were no significant differences between two groups in terms of operation time, blood loss, anesthesia time, time to first ambulation, and intraoperative fluid infusion (P>0.05). Pain scores at 24 hours and 48 hours postoperatively were significantly lower in the experimental group than in the control group (P<0.05), while there was no significant difference in pain scores at 2 hours postoperatively between the two groups (P>0.05). At 7 days and 14 days postoperatively, hip joint mobility was significantly higher in the experimental group compared to the control group, and at 14 days postoperatively, hip joint mobility improved significantly in both groups (P<0.05). Serum levels of TLR4 and NF-κB at 24 hours and 48 hours postoperatively were significantly lower in the experimental group than in the control group (P<0.05), while there was no significant difference in serum levels of TLR4 and NF-κB before surgery between the two groups (P>0.05). During treatment, neither group experienced adverse reactions such as nausea, vomiting, or itching. Conclusion: Compound betamethasone combined with iliac fascia block effectively reduces pain intensity, improves hip joint mobility, and is associated with the expression of TLR4/NF-κB signaling pathway in patients undergoing THA, demonstrating safety and efficacy.
王可心, 刘忠, 王梦楠, 张亚楠, 张晨佳, 缪凡. 复方倍他米松联合髂筋膜阻滞通过调控TLR4/NF-κB信号通路 相关因子在髋关节置换患者术后镇痛中的作用[J]. 河北医学, 2024, 30(7): 1120-1125.
WANG Kexin, LIU Zhong, WANG Mengnan, et al. Clinical Efficacy of Compound Betamethasone Combined with Iliac Fascia Block in Postoperative Analgesia for Patients Undergoing Total Hip Arthroplasty: Effects on TLR4/NF-κB Signaling Pathway. HeBei Med, 2024, 30(7): 1120-1125.
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2024, Vol. 30 
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