Abstract：Objective: To investigate the correlation between serum intercellular adhesion molecule-1 (ICAM-1), Homocysteine (Hcy), and Monocyte chemotactic protein-1 (MCP-1) levels and vascular endothelial function in patients with retinal vein occlusion (RVO).Methods: A retrospective, double-blind method was used to analyze 95 patients with RVO admitted to our hospital from July 2020 to October 2023 as the RVO group, and 102 healthy people who underwent a physical examination in our hospital during the same period were selected as the normal control group. To compare the levels of ICAM-1, Hcy, MCP-1, vascular endothelial function [Endothelin-1 (ET-1), nitric oxide (NO)] between the two groups; to compare the levels of ICAM-1, Hcy, MCP-1, ET-1 and NO in the RVO group with different types of diseases; to compare the levels of ICAM-1, MCP-1, ET-1 and NO in the RVO group with different degrees of diseases; and to analyze the correlation between serum levels of ICAM-1, Hcy, MCP-1 and vascular endothelial function in RVO patients.Results: Serum ICAM-1, Hcy, MCP-1, and ET-1 levels were higher and NO levels were lower in the RVO group than in the control group (P<0.05); serum ICAM-1, Hcy, MCP-1, and ET-1 levels were higher and NO levels were lower in the CRVO patients than in the BRVO patients (P<0.05); ICAM-1, MCP-1, and ET 1levels: mild<moderate<severe, NO levels: mild>moderate>severe (P<0.05); serum ICAM-1, Hcy, MCP-1 levels were positively correlated with ET-1 levels and negatively correlated with NO levels (P<0.05).Conclusion: Serum ICAM-1, Hcy and MCP-1 levels are all abnormally elevated in RVO patients, and are correlated with ET-1 and NO to a certain extent. Detection of serum ICAM-1, Hcy and MCP-1 levels can be used to assess the status of vascular endothelial function injury, to facilitate early treatment.
[1] 欧扬,王逸之,林斌武,等.从湿辨治抗血管内皮生长因子治疗后视网膜静脉阻塞黄斑水肿的疗效观察[J].实用医学杂志,2023,39(6):762-767. [2] Xu H,Ge Y,Liu Y,et al.Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co-expression network module[J].IET Systems Biology,2022,16(1):28-41. [3] 崔小妮,刘阳子.急性脑梗死患者hs-CRP Hcy FIB表达与颈动脉狭窄相关性分析[J].贵州医药,2023,47(3):366-367. [4] 甘小林,鲁江.白内障患者房水血清中单核细胞趋化蛋白1 CXC趋化因子配体8检测水平及临床意义[J].山西医药杂志,2022,51(10):1096-1100. [5] 邵毅,张雨晴,周琼.视网膜静脉阻塞诊疗规范—2019年欧洲视网膜专家协会指南解读[J].眼科新进展,2020,40(6):501-504. [6] 庞璐,白世淼,庞午,等.探讨庞氏"目病多郁"论在视网膜静脉阻塞的临床应用[J].中国中医眼科杂志,2021,31(3):183-186. [7] 彭立,张小花,劳娜,等.康柏西普与雷珠单抗治疗视网膜静脉阻塞继发黄斑水肿的Meta分析[J].国际眼科杂志,2020,20(3):455-463. [8] 崔红培,娄彦蕊,武文忠,等.血府逐瘀汤合五苓散加减联合抗VEGF药物治疗气滞血瘀证视网膜中央静脉阻塞患者的临床疗效及对其血清NO、ET-1、VEGF的影响[J].世界中西医结合杂志,2023,18(6):1222-1226,1232. [9] 张韫洁,李新章,索南措,等.康柏西普联合视网膜激光光凝对缺血型视网膜中央静脉阻塞患者球结膜微循环指标和血管内皮功能的影响[J].现代生物医学进展,2021,21(22):4368-4371,4386. [10] 柳洁平,付艳广,张俊广,等.血清ICAM-1、VEGF水平与糖尿病视网膜病变患者微血管损伤的关系[J].山东医药,2020,60(16):47-49. [11] 孙雷涛,杜德勇,李勐,等.蛛网膜下腔出血后外泌体源性miR-630对微血管内皮细胞功能的影响[J].西安交通大学学报(医学版),2021,42(5):645-650. [12] Xiaoxia L,Su B,Bin D,et al.The predictive values of GGT and Hcy in the risk stratifications and prognoses of NSTE-ACS patients[J].American Journal of Translational Research,2021,13(8):9269-9277. [13] 马楠,何敬,霍红,等.视网膜中央静脉阻塞患者血清同型半胱氨酸水平变化及其与血管内皮功能的关系研究[J].中国医药导报,2023,20(18):112-115. [14] 刘玉平,孙晶晶,孙建标,等.Ozurdex对视网膜静脉阻塞合并黄斑水肿患者房水内VEGF、IL-6及MCP-1水平的影响[J].临床和实验医学杂志,2023,22(4):414-417. [15] Wenjun W,Yao L,Fuhua L,et al.Polypropylene crisper and 1-MCP delay the softening,lignification and transcription levels of related enzyme genes of golden needle mushrooms ( Flammulina velutipes )[J].Journal of Integrative Agriculture,2022,21( 1):249-260.
2024, Vol. 30 
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