Assessment Value of Proportion of Low-Density Distribution Area in RR Scatterplot Hcy and FAR for Evaluation of Disease Severity and Prognosis in Patients with Myocardial Infarction
QIAN Hua, TAN Mingyue, CHEN Shuping, et al
The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Xi'an 710000, China
Abstract：Objective: To analyze the evaluation value of the proportion of low-density distribution area in RR scatterplot (L), homocysteine (Hcy), and fibrinogen/albumin ratio (FAR) for disease severity and prognosis of myocardial infarction.Methods: A total of 220 patients with myocardial infarction admitted to our hospital from June 2020 to June 2022 were divided into low-grade group (grade Ⅰ~Ⅱ, n=135) and high-grade group (grade Ⅲ~Ⅳ, n=85) according to the Fillip classification standard at admission, and were divided into survival group (n=184) and death group (n=36) according to the discharge prognosis. L, Hcy, and FAR levels were measured among all study subjects at admission. Binary Logistic regression analysis was used to construct a prediction model with L, Hcy and FAR as variables, and the evaluated value of L, Hcy and FAR on severity and prognosis of myocardial infarction patients was analyzed by receiver characteristic operating curve (ROC).Results: The levels of L, Hcy, and FAR in the high-grade group were higher than those in the low-grade group (P<0.05); the levels of L, Hcy, and FAR in the death group were higher than those in the survival group (P<0.05). Logistic regression analysis showed that L, Hcy, and FAR were independent predictive indicators for disease severity and prognosis of myocardial infarction, with predictive models as follows: Y=-12.864+0.065×L+0.250×Hcy+0.892×FAR; Y=-13.367+0.435×Hcy+0.914×FAR. ROC curve analysis showed that the area under the curve (AUC) of combined evaluation of myocardial infarction severity by L, Hcy, and FAR was 0.897, with sensitivity of 95.29% and specificity of 78.52%, which was higher than that of each index evaluated alone (P<0.05); the AUC of combined evaluation of prognosis of myocardial infarction patients by L, Hcy, and FAR was 0.859, with sensitivity of 80.56% and specificity of 81.52%, which was higher than that of each index evaluated alone (P<0.05).Conclusion: L, Hcy, and FAR have certain evaluation value for disease severity and prognosis of myocardial infarction patients, and the efficacy of combined evaluation of the three indicators is significantly improved compared with each index evaluated alone.
钱华, 谭茗月, 陈姝萍, 李博涵, 刘艳. RR散点图低密度分布区占比 Hcy FAR对心肌梗死患者病情及预后的评估价值[J]. 河北医学, 2024, 30(6): 1026-1031.
QIAN Hua, TAN Mingyue, CHEN Shuping, et al. Assessment Value of Proportion of Low-Density Distribution Area in RR Scatterplot Hcy and FAR for Evaluation of Disease Severity and Prognosis in Patients with Myocardial Infarction. HeBei Med, 2024, 30(6): 1026-1031.
2024, Vol. 30 
冀公网安备13080202000677号