GRED对慢性阻塞性肺疾病患者血清IL-10 TGF-β<sub>1</sub> sPD-1和sPD-L1表达水平及临床表现的影响

doi:10.3969/j.issn.1006-6233.2024.04.09

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摘要 目的: 分析胃食管反流病(GRED)对慢性阻塞性肺疾病(COPD)患者血清白细胞介素-10(IL-10)、转化生长因子-β₁(TGF-β₁)、可溶性程序性死亡受体-1(sPD-1)和sPD-1配体(sPD-L1)表达水平及临床表现的影响。方法: 选取我院2022年1月至2023年9月收治的104例COPD患者,按照患者是否合并反流性疾病,将其分别纳入合并组、未合并组。对比两组肺功能、IL-10、TGF-β₁、sPD-L1和sPD-1表达水平及临床表现差异。结果: 104例COPD患者中,32例合并GERD,占30.77%。合并组IL-10低于未合并组,其TGF-β₁、sPD-1、sPD-L1均高于未合并组,差异有统计学意义(P<0.05)。合并组FEV1、FEV1/FVC、FEV1%均低于未合并组,差异有统计学意义(P<0.05)。合并组CASA-Q问卷咳嗽症状、咳嗽影响、咳痰症状、咳痰影响评分,以及mMRC评分和SGRQ问卷各项目评分、总分均高于未合并组,差异有统计学意义(P<0.05)。结论: 近1/3的COPD患者合并GERD,且GERD与患者更为强烈的炎症反应和sPD-1、sPD-L1高表达有关,并伴有更差的肺功能和更严重的临床表现。

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	许腾
	郝立君
	刘红春
	崔彦杰

关键词 ：慢性阻塞性肺疾病, 反流性疾病, 可溶性程序性死亡受体

Abstract：Objective: To analyze the influence of gastroesophageal reflux disease (GRED) on the expression levels and clinical manifestations of serum interleukin -10(IL-10), transforming growth factor -β₁(TGF-β₁), soluble programmed death receptor -1(sPD-1) and sPD-1 ligand (sPD-L1) in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 104 COPD patients admitted to our hospital from January 2022 to September 2023 were divided into combined group and non-combined group according to whether the patients were complicated with reflux disease. The lung function, IL-10, TGF-β₁, sPD-L1 and sPD-1 expression levels and clinical manifestations were compared between the two groups. Results: Among 104 COPD patients, 32 cases were complicated with GERD, accounting for 30.77%. IL-10 in the combined group was lower than that in the non-combined group, and its TGF-β₁, sPD-1 and sPD-L1 were higher than those in the non-combined group, with statistical significance (P<0.05). FEV1, FEV1/FVC and FEV1% in the combined group were lower than those in the non-combined group, and the difference was statistically significant (P<0.05). The combined group had higher cough symptoms, cough effects, expectoration symptoms, expectoration effects scores, mMRC scores, SGRQ scores and total scores than the non-combined group, and the difference was statistically significant (P<0.05). Conclusion: Nearly one third of COPD patients are complicated with GERD, and GERD is related to the stronger inflammatory reaction and the high expression of sPD-1 and sPD-L1, accompanied by worse lung function and more serious clinical manifestations.

Key words： Chronic obstructive pulmonary disease Reflux disease Soluble programmed death receptor

基金资助:新疆维吾尔自治区自然科学基金资助项目,(编号:2021D01C152)

通讯作者: 郝立君

引用本文:

许腾, 郝立君, 刘红春, 崔彦杰. GRED对慢性阻塞性肺疾病患者血清IL-10 TGF-β₁ sPD-1和sPD-L1表达水平及临床表现的影响[J]. 河北医学, 2024, 30(4): 575-579.
XU Teng, HAO Lijun, LIU Hongchun, et al. Effect of Reflux Disease on the Expression Levels and Clinical Manifestations of Serum IL-10 TGF-β₁ sPD-1 and sPD-L1 in Patients with Chronic Obstructive Pulmonary Disease. HeBei Med, 2024, 30(4): 575-579.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.04.09 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I4/575

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