A Study on the Value of Combined Mid-Pregnancy Serum Freeβ-hCG and uE3 Screening for Severe Congenital Heart Disease in Pregnant Women Using the "Four-Plane" Method of Ultrasound
LI Bo, ZHANG Huanhuan, QU Donghui, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To investigate the clinical application value of the "four-plane" method of ultrasound combined with mid-pregnancy maternal serum free human chorionic gonadotropin (Freeβ-hCG) and estriol (uE3) for screening severe congenital heart disease (CHD) in fetuses. Methods: A total of 97 pregnant women who underwent mid-pregnancy CHD screening in our hospital from January 2020 to June 2021 were selected. The maternal serum Freeβ-hCG and uE3 levels were detected, and the "four-plane" method of ultrasound was used to screen for CHD. The diagnostic value of the "four-plane" method of ultrasound combined with serum Freeβ-hCG and uE3 levels for CHD was analyzed. Results: A total of 9 cases (9/97, 9.28%) of severe CHD were confirmed by follow-up; 25 cases of high-risk fetuses were detected by the "four-plane" method of ultrasound, of which 4 cases were confirmed to have severe CHD (4/25, 16.00%); 36 cases of high-risk fetuses were detected by maternal serum biochemical test, of which 6 cases were finally confirmed to have severe CHD (6/36, 16.67%); and 9 cases of high-risk fetuses were detected by the combined "four-plane" method of ultrasound and maternal serum biochemical test, of which 5 cases were confirmed to have severe CHD (5/9, 55.56%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the "four-plane" method of ultrasound for screening severe CHD were 16.00%, 93.51%, 74.51%, 44.44%, and 77.22%, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of maternal serum Freeβ-hCG and uE3 levels for screening severe CHD were 55.56%, 95.31%, 92.08%, 66.67%, and 64.00%, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the combined screening for severe CHD were 55.56%, 95.65%, 92.08%, 55.56%, and 91.09%, respectively. The diagnostic results of the combined detection were higher than those of the single detection method (P<0.05). Conclusion: The "four-plane" method of ultrasound has a high diagnostic value for screening severe CHD in pregnant women in mid-pregnancy. The combination of maternal serum Freeβ-hCG and uE3 levels can further improve the diagnostic accuracy and has good clinical application value.
李博, 张欢欢, 曲东辉, 王锟, 刘天鑫, 吴文瑛. 超声“四切面”法联合妊娠中期产妇血清Freeβ-hCG和uE3筛查胎儿严重先天性心脏病的研究[J]. 河北医学, 2024, 30(4): 665-669.
LI Bo, ZHANG Huanhuan, QU Donghui, et al. A Study on the Value of Combined Mid-Pregnancy Serum Freeβ-hCG and uE3 Screening for Severe Congenital Heart Disease in Pregnant Women Using the "Four-Plane" Method of Ultrasound. HeBei Med, 2024, 30(4): 665-669.
2024, Vol. 30 
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