Abstract：Objective: To explore the relationship between immunoglobulin A (IgA), D-dimer (D-D), fibrinogen degradation products (FDP) levels, and disease recurrence in children with Henoch-Schonlein Purpura (HSP).Methods: A total of 160 children with HSP admitted to our hospital from November 2022 to April 2023 were selected as the study subjects. IgA levels were measured using a fully automatic biochemical analyzer, and D-D and FDP levels were determined using a fully automatic blood coagulation analyzer. After a 6-month follow-up, the patients were divided into the recurrence group (n=34) and the non-recurrence group (n=136) based on the follow-up results. The levels of IgA, D-D, and FDP were compared between the two groups. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to analyze the predictive value of each indicator for disease recurrence. Multifactorial logistic regression analysis was employed to assess the impact of various indicators on disease recurrence. Results: Children in the recurrence group had higher levels of IgA [3.305 (2.565, 4.402)g/L], D-D [1.470 (0.477, 2.742)μg/mL], and FDP [4.445 (2.442, 9.212)μg/mL] compared to the non-recurrence group with IgA [2.360 (1.697, 3.012)g/L], D-D [0.310 (0.200, 0.575)μg/mL], and FDP [1.920 (1.140, 2.890)μg/mL], and the differences were statistically significant (P<0.05). ROC curve analysis revealed that the AUC for the combined prediction of IgA, D-D, and FDP for disease recurrence in HSP children was 0.892, higher than individual indicators, with a sensitivity of 85.3% and specificity of 82.5%. Multifactorial logistic analysis showed that IgA>3.235 g/L, D-D>0.415 μg/mL, and FDP>3.260μg/mL were independent factors for HSP recurrence (P<0.05). Conclusion: IgA, D-D, and FDP levels have a certain predictive value for disease recurrence in HSP. Monitoring the levels of these three indicators is beneficial for evaluating the prognosis.
杨扬, 唐帅, 张建. 过敏性紫癜患儿IgA D-D FDP水平与疾病复发的关系[J]. 河北医学, 2024, 30(3): 484-487.
YANG Yang, TANG Shuai, ZHANG Jian. Relationship between Levels of IgA, D-Dimer, and Fibrinogen Degradation Products and Disease Recurrence in Children with Henoch-Schonlein Purpura. HeBei Med, 2024, 30(3): 484-487.
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2024, Vol. 30 
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