Effects of Sintilimab Combined with Chemotherapy on Short-Term Efficacy and Serum CEA, sTim-3 sLAG-3 and T Lymphocyte Subsets in Patients with Advanced Gastric Cancer
LIU Zhao, REN Yuchuan, ZHANG Yapeng, et al
Yangquan First People' s Hospital, Shanxi Yangquan 045000, China
Abstract：Objective: To investigate the effects of Sintilimab combined with chemotherapy on short-term efficacy and serum carcinoembryonic antigen (CEA), immune function, and T lymphocyte subsets in patients with advanced gastric cancer. Methods: A total of 84 patients with advanced gastric cancer treated from May 2020 to May 2022 were randomly divided into an observation group and a control group (42 cases each). The control group received conventional chemotherapy, while the observation group received additional Sintilimab. Both groups underwent three cycles of continuous treatment (3 months). Clinical outcomes after 1 month of chemotherapy, occurrence of toxicities, and changes in serum tumor markers (CA, CEA, MG-Ag), immune function (sTim-3, sLAG-3), and T lymphocyte subsets (CD3+, CD4+, CD8+) were compared between the two groups before and after 3 cycles of treatment. The 1-year survival rate was recorded during follow-up. Results: After 1 month of chemotherapy, the observation group showed a higher clinical effective rate compared to the control group, with no significant differences in toxicities (P>0.05). After 3 cycles of treatment, both groups exhibited significant reductions in CA, CEA, MG-Ag, sTim-3, and sLAG-3 levels, and the observation group had lower levels than the control group (all P<0.05), CD3+ and CD4+ levels decreased, with the observation group higher than the control group, while CD8+ levels increased, and the observation group had lower levels than the control group (all P<0.05). The 1-year survival rate in the observation group was significantly higher than in the control group (P<0.05). Conclusion: Sintilimab combined with chemotherapy demonstrates significant short-term efficacy, high safety, and the ability to improve immune function in patients with advanced gastric cancer, thereby alleviating the tumor burden.
刘昭, 任玉川, 张亚鹏, 吕晓燕, 张立平. 信迪利单抗联合化疗对晚期胃癌患者近期疗效及血清CEA sTim-3 sLAG-3和T淋巴细胞亚群的影响[J]. 河北医学, 2024, 30(2): 335-340.
LIU Zhao, REN Yuchuan, ZHANG Yapeng, et al. Effects of Sintilimab Combined with Chemotherapy on Short-Term Efficacy and Serum CEA, sTim-3 sLAG-3 and T Lymphocyte Subsets in Patients with Advanced Gastric Cancer. HeBei Med, 2024, 30(2): 335-340.
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2024, Vol. 30 
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