Serum Levels of Carbohydrate Antigen 125 (CA125) Growth Differentiation Factor-15 (GDF-15) and Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Patients with Chronic Heart Failure and their Correlation with Cardiac Function: An Analysis
ZHANG Guoyong, MA Zheng, ZHANG Lin, et al
Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China
Abstract：Objective: To explore the expression of serum carbohydrate antigen 125(CA125), growth differentiation factor -15(GDF-15) and soluble myeloid cell trigger receptor -1(sTREM-1) in patients with chronic heart failure and their correlation with cardiac function. Methods: The clinical data of 96 patients with CHF admitted to our hospital from June 2022 to June 2023 were analyzed retrospectively, including 46 patients with mild and moderate heart failure (NYHA grade Ⅰ-Ⅲ) and 50 patients with severe heart failure (NYHA grade Ⅳ). In addition, 48 healthy people who underwent physical examination in our hospital during the same period were selected as the healthy control group according to the ratio of 2:1. The serum levels of CA125, GDF15 and sTREM-1 were compared with the cardiac function indexes, and the correlation between the serum levels of CA125, GDF15 and sTREM-1 and the cardiac function indexes was analyzed. The ROC curve was used to analyze the efficacy of serum levels of CA125, GDF15 and sTREM-1 in diagnosing chronic heart failure. Results: The levels of CA125, GDF15, and sTREM-1 in the study group were higher than those in the control group (P<0.05). FS and EF in the study group were lower than those in the control group, while LAD and LVEDD were higher than those in the control group (P<0.05). Person correlation analysis showed that CA125, GDF15, and sTREM-1 were negatively correlated with FS and EF (r=-0.605/-0.617, -0.516/-0.512, -0.572/-0.613, P<0.05), and positively correlated with LAD and LVEDD (r=0.827/0.818, 0.819/0.834, 0.846/0.878, P<0.05). The levels of CA125, GDF15, and sTREM-1 in the severe heart failure group were higher than those in the mild to moderate heart failure group (P<0.05). Binary Logistic Regression Analysis showed that serum CA125, GDF15, and sTREM-1 were risk factors for severe heart failure (P<0.05). The AUC, sensitivity, and specificity of serum CA125, GDF15, and sTREM-1 in evaluating the severity of chronic heart failure were 0.761, 0.695, and 0.822, respectively. The AUC for assessing the severity of chronic heart failure by prediction scoring ROC curves was 0.848 with a sensitivity of 84.0% and a specificity of 82.6%. Conclusion: Serum levels of CA125, GDF15, and sTREM-1 are upregulated in patients with CHF and are closely related to cardiac function. They can be used as effective indicators to evaluate the severity of heart failure, with better combined evaluation performance.
2024, Vol. 30 
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