Efficacy of Trastuzumab Combined with Pertuzumab in the Treatment of HER2-Positive Breast Cancer and Its Impact on Serum miR-375 and miR-30d Expression
TANG Youqiong, ZHANG Qi, TAN Daofu, et al
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Enshi 445000, China
Abstract：Objective: To observe the efficacy of combination of trastuzumab and pertuzumab in treating human epidermal growth factor receptor-2 (HER2)-positive breast cancer and the effects on changes of expressions of serum microRNA-375 (miR-375) and microRNA-30d (miR-30d). Methods: From February 2020 to February 2023,a total of 139 patients with HER2-positive breast cancer were randomly assigned to the combined group (n=70,receiving trastuzumab and pertuzumab) and the control group (n=69,receiving trastuzumab) using a simple random number table and random remainder grouping method.Each patient received one course of treatment every 21 days,and a total of four courses were administered.Clinical efficacy,tumor-related indicators (including carbohydrate antigens CA125 and CA153,carcinoembryonic antigen CEA,and circulating tumor cells CTC),T lymphocyte subsets (CD3+,CD4+,CD8+,CD4+/CD8+),serum microRNA expression (miR-375 and miR-30d),and changes in quality of life (assessed using the Quality of Life Questionnaire-Cancer QLQ-C30) were compared between the two groups before and after treatment.Adverse reactions were also documented. Results: No patient died during the course of treatment in both groups.The total clinical effective rate was significantly higher in the combined group compared to the control group (P<0.05).After four courses of treatment,both groups exhibited reductions in serum CA125,CA153,CEA,CTC positive rate,CD8+ levels,and miR-375 and miR-30d expression,as well as improvements in QLQ-C30 scores compared to baseline (P<0.05).Additionally,serum CD3+,CD4+,and CD4+/CD8+ levels were elevated in both groups post-treatment compared to baseline,with the combined group displaying higher levels compared to the control group (P<0.05).Notably,the difference values of various indicators were significantly higher in the combined group compared to the control group (P<0.05).Adverse reactions were effectively managed,with a higher incidence of palpitations observed in the combined group (P<0.05). Conclusion: Trastuzumab combined with pertuzumab effectively enhances immune function,reduces tumor marker levels,modulates the expression of miR-375 and miR-30d,and improves the quality of life for HER2-positive breast cancer patients.Moreover,this treatment approach demonstrates a high safety profile and significant clinical efficacy.
唐友琼, 张棋, 谭道富, 张思波, 吴谦. 曲妥珠单抗结合帕妥珠单抗治疗HER2阳性乳腺癌的疗效及对血清miR-375 miR-30d表达变化的影响[J]. 河北医学, 2023, 29(11): 1916-1922.
TANG Youqiong, ZHANG Qi, TAN Daofu, et al. Efficacy of Trastuzumab Combined with Pertuzumab in the Treatment of HER2-Positive Breast Cancer and Its Impact on Serum miR-375 and miR-30d Expression. HeBei Med, 2023, 29(11): 1916-1922.
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2023, Vol. 29 
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