Abstract：Objective: To explore the correlation between the expression levels of miR-30a,miR-24 and Sestrin2 in peripheral blood and the degree of myocardial injury in AMI patients in order to evaluate its potential clinical value in myocardial infarction. Methods: The study included 180 patients who were diagnosed with acute ST-segment elevation myocardial infarction between January 2020 and January 2023.A control group consisting of 100 age-matched individuals without cardiac conditions was also established.The study compared the peripheral blood levels of miR-30a,miR-24,and Sestrin2 between the two groups.Coronary angiography was performed on the patients to assess the extent of myocardial injury.Patients in the study group were categorized into mild and severe groups based on the severity of myocardial injury.The study also analyzed the correlation between peripheral blood miR-30a,miR-24,and Sestrin2 expression and levels of cardiac markers (CK,CK-MB,LDH,and hs-cTnI). Results: Compared to the control group,patients in the study group showed increased relative expression levels of miR-30a and Sestrin2,and decreased relative expression of miR-24 (P<0.05).Within the study group,patients in the severe myocardial injury group exhibited higher relative expression levels of miR-30a and Sestrin2,and lower relative expression of miR-24 compared to the mild group (P<0.05).Additionally,CK,CK-MB,LDH,and hs-cTnI levels were elevated in the severe group when compared to the mild group (P<0.05).Peripheral blood miR-30a and Sestrin2 levels were positively correlated with levels of CK,CK-MB,LDH,and hs-cTnI,while miR-24 expression was negatively correlated with these cardiac markers (P<0.05).Using the degree of myocardial injury as a variable,the study analyzed the diagnostic value of peripheral blood levels of miR-30a and miR-24 as well as Sestrin2.The AUC values for each index were 0.942,0.989,and 0.862,respectively. Conclusion: In patients with acute myocardial infarction,those with severe myocardial injury had higher levels of miR-30a and Sestrin2 and lower levels of miR-24.The study also revealed a significant correlation between the expression of peripheral blood miR-30a,miR-24,and Sestrin2 and the extent of myocardial injury.These findings suggest that these markers could serve as potential biomarkers for assessing the degree of myocardial injury in AMI patients,providing a basis for risk stratification and guiding clinical treatment decisions in AMI patients.
汪彪, 陈见红, 吴刚, 莫纪南. 外周血miR-30a miR-24及Sestrin2表达与急性心肌梗死患者心肌损伤程度的相关性[J]. 河北医学, 2023, 29(11): 1821-1826.
WANG Biao, CHEN Jianhong, WU Gang, et al. Correlation between Peripheral Blood Levels of miR-30a miR-24 and Sestrin2 and the Extent of Myocardial Injury in Acute Myocardial Infarction Patients. HeBei Med, 2023, 29(11): 1821-1826.
2023, Vol. 29 
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