Analysis of the Predictive Value of Peripheral Blood PT PTA and PLT Levels for Progression of Primary Liver Cancer in Patients with Chronic Hepatitis B
NIU Xingjie, LIU Zhihui, WANG Yanfei, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To analyze the predictive value of platelet count (PLT), prothrombin time (PT) and prothrombin activity (PTA) in hepatocellular carcinoma after hepatitis B. Methods: A total of 161 patients with chronic hepatitis B who were hospitalized from January 2017 to December 2019 were selected. They were divided into two groups according to whether there was abnormal coagulation (n=76) and normal coagulation (n=85). At the same time, the demography data and clinical data of patients were recorded. The observation results were observed for three consecutive years. A comparative analysis was carried out to find 46 patients with primary liver cancer. Single factor and multi factor analysis were carried out for patients with liver cancer. The predictive value of PLT, PT, and PTA for primary liver cancer was evaluated using the receiver operating characteristic (ROC) curve. Results: The differences in ALT, AST, and AFP levels between the two groups were statistically significant (P<0.05). The levels of PLT, PTA and PT in chronic hepatitis B group and primary liver cancer group were significantly different (P<0.05). Using statistically significant variables in univariate analysis as independent variables and the occurrence of primary liver cancer as dependent variables for multivariate logistic regression analysis, the results showed that PLT (OR=3.525), PTA (OR=215), and PT (OR=2.312) were the influencing factors for the occurrence of primary liver cancer in patients (P<0.05). The area under the receiver operating characteristic of PLT, PT and PTA was 0.790, 0.744 and 0.682, respectively, which had statistical significance in predicting the development of hepatocellular carcinoma in patients with hepatitis B (P<0.001). Conclusion: PLT, PTA, and PT have a good predictive value in the progression of hepatitis B virus related hepatocellular carcinoma, and the ability of PTA and PT is better than PLT.
牛兴杰, 刘志慧, 王艳飞, 刘耀敏, 张国民. 外周血PT PTA PLT水平对慢性乙肝患者进展原发性肝癌预测价值分析[J]. 河北医学, 2023, 29(10): 1668-1672.
NIU Xingjie, LIU Zhihui, WANG Yanfei, et al. Analysis of the Predictive Value of Peripheral Blood PT PTA and PLT Levels for Progression of Primary Liver Cancer in Patients with Chronic Hepatitis B. HeBei Med, 2023, 29(10): 1668-1672.
[1] 胡素玲,栗红江,何久胜,等.Fibroscan硬度值测量联合超声影像参数对慢性乙型肝炎纤维化的诊断价值[J].中国医学装备,2020,17(11):73-77. [2] Mauroe,Crespog,Montironic,et al.Portalpressure And liver stiffness measure ments in the prediction of fibrosisre-gression after sustain edvirolo gicalresponse inrecurren the patitis C[J].Hepatology:Official Journal of the American Association For the Study of Liver Diseases,2018,67(5):1683-1694. [3] 程小飞,梁雄波,熊晓青,等.多普勒超声测定乙型肝炎肝硬化患者肾动脉血流参数与 Fibroscan 测值的相关性分析[J].中国肝脏病杂志(电子版),2016,8(2):107-109. [4] 余小龙,罗晓莉,金善丰,等.血清PIVKA-Ⅱ、AFP、AFP-L3%联合检测在原发性肝癌诊断中的应用价值[J].中国现代药物应用,2023,17(10):63-66. [5] 张英檀,李佩佩,陈晓,等.术前Ki-67联合多模态超声检查对原发性肝癌微血管侵犯的预测价值[J].中国超声医学杂志,2022,38(11):1248-1251. [6] 王贵强,王福生,成军,等.慢性乙型肝炎防治指南(2015年更新版)[J].临床肝胆病杂志,2015,31(12):1941-1960. [7] Baccouche H,Labidi A,Fekih M,etal.Haemostatic balance incirrhosis[J].BloodCoagul Fibrinolysis,2017,28(2):139-144. [8] 陈月燕,王潭枫,陈文思,慢性乙型病毒性肝炎患者PT、APTT、FIB临床价值再评价.[J].新医学,2007,38(8):519-520. [9] Alvaro D,Caporaso N,Giannini EG,et al.Procedure-related bleeding risk in patients with cirrhosis and severe thrombocytopenia[J].Eur Clin Invest,2021,51(6):e13508. [10] Nilles KM,Flamm SL.Thrombocytopenia in chronic liver disease:new management strategies[J].Clin Liver Dis,2020,24(3):437-451.
2023, Vol. 29 
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