Abstract：Objective: To investigate the effect of low-dose Esketamine combined with sufentanil on postoperative intravenous analgesia after gynecological laparoscopic surgery. Methods: A total of 80 cases of elective gynecological laparoscopic myomectomy were randomly divided into S group and KS group, with 40 cases in each group. Both groups of patients were given general anesthesia and PCIA analgesia after operation. Group S: sufentanil 50 μ g+ondansetron 8 mg, group KS: sufentanil 25 μ g+esketamine 25 mg+ondansetron 8 mg, and 0.9% sodium chloride was added to 50ml. To evaluate the postoperative analgesia effect of the two groups, the main monitoring indicators were VAS at 2h (T1), 6h (T2) and 24h (T3) after operation, and the secondary indicators were MAP, HR and PCIA press times, adverse reactions within 24h, preoperative and postoperative anxiety and depression (HADS scale), and postoperative analgesia satisfaction. Results: VAS of S group at T2 and T3 was higher than that of KS group (P<0.05), and there was no significant difference between the two groups at T1 (P>0.05). The number of PCIA single press in group S was higher than that in group KS (P<0.01). In T1, T2 and T3, there was no significant difference in MAP and HR between the two groups (P>0.05). The score of HADS-A in group S was significantly higher than that in group KS (P<0.05). The number of cases of adverse reactions such as drowsiness and skin itching in group S was higher than that in group KS (P<0.05), while the number of cases of nausea, vomiting and dizziness was not statistically significant (P>0.05). The percentage of pain relief and satisfaction of postoperative analgesia in group S were lower than those in group KS. Conclusion: Low-dose Esketamine combined with sufentanil for intravenous analgesia after gynecological endoscopic surgery has a good analgesic effect, reduces adverse reactions, and improves patients' satisfaction with postoperative analgesia.
王馨, 王媛, 孙艳斌, 姚晶晶, 刘广飞, 岳洁. 艾司氯胺酮用于妇科腹腔镜下子宫肌瘤剔除术后镇痛的效果观察[J]. 河北医学, 2023, 29(8): 1382-1387.
WANG Xin, WANG Yuan, SUN Yanbin, et al. Observation of the Analgesic Effect of Esketamine after Hysteromyomectomy under Gynecological Laparoscopy. HeBei Med, 2023, 29(8): 1382-1387.
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2023, Vol. 29 
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