HPV感染与ERK信号通路关键因子在宫颈癌中的交互效应及临床意义

doi:10.3969/j.issn.1006-6233.2023.06.015

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摘要 目的: 探讨HPV感染与ERK信号通路关键因子在宫颈癌中的交互效应及意义。方法: 选取2020年10月至2022年10月我院收治的宫颈癌患者90例,作为研究组,另纳入宫颈上皮内瘤变患者90例,作为对照组。统计两组HPV感染状况、ERK信号通路关键因子[核不均一核糖核蛋白E1(HnRNP E1)、磷酸化细胞外信号调节激酶1/2(p-ERK1/2)、磷酸化非受体酪氨酸激酶(p-Src)]表达,比较研究组不同临床病理特征患者ERK信号通路关键因子表达,Spearman分析两者间相关性,Logi.0stic回归方程分析HPV感染与ERK信号通路关键因子在宫颈癌中的交互效应。结果: 研究组HPV感染率及HnRNP E1、p-ERK1/2、p-Src蛋白阳性率均高于对照组CIN Ⅰ~Ⅱ、Ⅲ级(P<0.05);宫颈癌患者FIGO分期、HPV感染、分化程度与HnRNP E1、p-ERK1/2、p-Src蛋白呈正相关(P<0.05);HnRNP E1、p-ERK1/2、p-Src蛋白及三者交互作用是宫颈癌患者HPV感染高危因素(P<0.05)。结论: HPV感染及ERK信号通路关键因子阳性表达均可增加宫颈癌发病风险,两者存在正向交互作用,可为宫颈癌鉴别诊治提供有利参考信息。

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	张晓敏
	杨年红

关键词 ：宫颈癌, HPV感染, ERK信号通路, 核不均一核糖核蛋白E1, 磷酸化细胞外信号调节激酶1/2, 磷酸化非受体酪氨酸激酶

Abstract：Objective: To investigate the interactive effects and significance of HPV infection and key factors of ERK signaling pathway in cervical cancer. Methods: Ninety patients with cervical cancer admitted to our hospital from October 2020 to October 2022 were selected as the study group, and another 90 patients with cervical intraepithelial neoplasia were included as the control group. The HPV infection status, ERK signaling pathway key factors [nuclear inhomogeneous ribonucleoprotein E1 (HnRNP E1), phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), and phosphorylated non-receptor tyrosine kinase (p-Src)] expression were counted in both groups, and the expression of ERK signaling pathway key factors in patients with different clinicopathological characteristics in the study group was compared. The correlation between the two was analyzed with Spearman analysis and Logistic regression equation analysis was conducted to determine the interaction effect between HPV infection and key factors of the ERK signaling pathway in cervical cancer. Results: The HPV infection rate and the positive rates of HnRNP E1, p-ERK1/2 and p-Src protein in the study group were higher than those in the control group for CIN grade Ⅰ~Ⅱ and Ⅲ (P<0.05); the FIGO stage, HPV infection and differentiation degree of cervical cancer patients were positively correlated with HnRNP E1, p-ERK1/2 and p-Src protein (P<0.05); HnRNP E1, p-ERK1/2, p-Src protein and the interaction of the three were high-risk factors for HPV infection in cervical cancer patients (P<0.05). Conclusion: Both HPV infection and positive expression of key factors of ERK signaling pathway can increase the risk of cervical cancer, and there is a positive interaction between the two, which can provide favorable reference for the identification and treatment of cervical cancer.

Key words： Cervical cancer HPV infection ERK signaling pathway HnRNP E1 p-ERK1/2 P-Src

基金资助:2021年恩施州科技计划拟立项项目,(编号:JCY2021000014)

引用本文:

张晓敏, 杨年红. HPV感染与ERK信号通路关键因子在宫颈癌中的交互效应及临床意义[J]. 河北医学, 2023, 29(6): 957-962.
ZHANG Xiaomin, YANG Nianhong. Interactive Effects of HPV Infection and Key Factors of the ERK Signaling Pathway in Cervical Cancer and Clinical Implications. HeBei Med, 2023, 29(6): 957-962.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.06.015 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I6/957

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