Abstract：Objective: To investigate the correlation between the changes in the expression levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in invasive pituitary adenoma tissues and their significance. Methods: Fifty-six patients with pituitary adenomas surgically resected in the neurosurgery department of Chengde Central Hospital were selected and divided into patients with non-functional invasive pituitary adenomas (observation group, 38 patients) and non-functional non-pituitary adenomas (control group, 18 patients) according to the invasiveness of the tumor. The expression levels of TNF-α,, IL-6 and VEGF in the observation and control groups were measured by real-time quantitative PCR and immunohistochemistry to understand the role of the three in the aggressive growth of pituitary adenomas. Results: The expression levels of TNF-α, IL-6 and VEGF mRNA were higher in the observation group than in the control group (all P<0.05), and the results of immunohistochemical staining also showed that the expression of TNF-α, IL-6 and VEGF were higher in the observation group than in the control group, and the differences were of high research value and statistical significance (all P<0.05) . Conclusion: High expression of TNF-α, IL-6 and VEGF in pituitary adenoma tissues may predispose pituitary adenomas to aggressive growth, and low or no expression may lead to even less aggressive or non-invasive growth. TNF-α, IL-6 and VEGF may contribute to aggressive pituitary adenoma growth.
刘思洋, 吴建龙, 梅赞, 苏彬, 王学文齐迎松, 李斌斌, 王婷婷, 张金利, 高继刚. 侵袭性垂体腺瘤中TNF-α IL-6及VEGF之间表达水平变化的相关性研究[J]. 河北医学, 2023, 29(6): 933-936.
LIU Siyang, WU Jianlong, MEI Zan, et al. Correlation Study of the Changes in Expression Levels between TNF-α IL-6 and VEGF in Invasive Pituitary Adenoma. HeBei Med, 2023, 29(6): 933-936.
2023, Vol. 29 
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