Abstract：Objective: To analyze the predictive value of continuous monitoring of intracranial pressure (ICP) by transcranial Doppler (TCD) for early neurological deterioration (END) after thrombolysis in acute cerebral infarction. Methods: The clinical data of 109 patients with acute cerebral infarction treated by thrombolytic therapy in our hospital from January 2019 to January 2022 were retrospectively analyzed. According to the occurrence of END, the patients were divided into END group and non-END group respectively. The clinical data of the two groups and the difference of ICP changes during treatment were compared, and the multivariate logistic regression was used to analyze the influencing factors of END. Results: Among the 109 patients, 28 cases (25.69%) had END. 26 cases (92.86%) in END group had ICP increase during TCD monitoring, which was higher than 43.21% in non-END group, and the difference was statistically significant (P<0.05). Logistic regression analysis showed that increased ICP, BMI≥28.0 kg/m2, baseline NIHSS score ≥10, and large area infarction were all indepENDent risk factors for the end of acute cerebral infarction after thrombolysis (P<0.05). Conclusion: The incidence of END is high after thrombolysis in acute cerebral infarction, and the ICP is generally increased in patients with END during treatment. Combined with the factors of ICP increase, obesity, high NIHSS score at baseline, massive infarction and so on, it is expected to provide a reliable reference for the prediction of END in patients.
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2023, Vol. 29 
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