Abstract：Objective: To explore the effect of Bio-Oss bone meal combined with PRF and GBR technology on peri-implant bone regeneration and peri-implantitis. Methods: A total of 90 patients who underwent oral implant-guided bone regeneration in our hospital from February 2020 to April 2022 were selected as the research subjects, and divided into 3 groups according to the order of admission. Thirty cases in the Bio-Oss group were given Bio-Oss bone meal combined with guided bone regeneration (GBR) for guided regeneration, 30 cases in the PRF group were given platelet-rich fibrin (PRF) combined with GBR technique for guided regeneration, and 30 cases in the combined group were given Bio-Oss bone meal Combined PRF and GBR technology to guide regeneration. The peri-implant bone regeneration at 1 month and 3 months after operation among the three groups, pain at 24 hours after the operation, mucosal swelling at the surgical site at 1 week after the operation, and the plaque index (PLI) before surgery, 1 month, and 3 months after surgery probing depth (PD), and postoperative complications were compared among the three groups. Results: At 1 month and 3 months after the operation, the height of the bone graft and the thickness of bone formation in the combined group were significantly higher than those in the Bio-Oss group and the PRF group (P<0.05). There was no significant difference in the bone graft height and bone formation thickness between the Bio-Oss group and the PRF group (P>0.05); 24 hours after the operation, the pain in the combined group was significantly better than that in the other two groups (P<0.05), while there was no significant difference between the other two groups (P>0.05). One week after the operation, the mucosal swelling in the combined group was significantly lighter than that in the Bio-Oss group and the PRF group (P<0.05), while there was no significant difference between the Bio-Oss and PRF groups (P>0.05). At 1 month and 3 months after the operation, the PLI and PD of the three groups were significantly lower than those before the operation (P<0.05). And the PLI score and PD of the combined group were significantly lower than those of the Bio-Oss group and the PRF group(P<0.05). However, there was no significant difference between the PRF group and the Bio-Oss group (P>0.05). There was no significant difference in the total incidence of postoperative complications among the three groups (P>0.05). Conclusion: The application of Bio-Oss bone powder combined with PRF and GBR technology in oral implant-guided bone regeneration can help promote postoperative bone defect regeneration, reduce postoperative pain, promote soft tissue regeneration, reduce mucosal swelling, and promote obvious peri-implant soft tissue inflammation improved, and the safety is high, which is worthy of clinical application.
黄徐琛, 高琴. Bio-Oss骨粉联合PRF及GBR技术对种植体周围骨再生及种植体周围炎的影响[J]. 河北医学, 2023, 29(2): 275-280.
HUANG Xuchen, et al. Effects of Bio-Oss Bone Meal Combined with PRF and GBR Technology on Peri-Implant Bone Regeneration and Peri-Implantitis. HeBei Med, 2023, 29(2): 275-280.
2023, Vol. 29 
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