Abstract：Objective: To investigate the expressions and clinical significance of P120 catenin (P120ctn), p53 protein, and cytokeratin 5/6 (CK5/6) in cancer tissues of patients with invasive breast carcinoma (IBC). Methods: The clinical data of 120 patients with IBC were retrospectively analyzed between October 2018 and October 2021. Immunohistochemistry was used to detect the expressions of CD31, p53, and CK5/6 in cancer tissues and adjacent tissues, and their relationship with the clinicopathological characteristics and preoperative neoadjuvant chemotherapy (NAC) efficacy were analyzed. Results: The positive expression rates of P120ctn, p53, and CK5/6 in cancer tissues were 81.67%, 75.83%, and 38.33%, which were significantly higher than 55.00%, 15.00%, and 3.25% in adjacent tissues (all P<0.05). P120ctn expression was correlated with molecular typing and lymph node metastasis (P<0.05), p53 was related to tumor diameter, molecular typing, histological grading, lymph node metastasis, and clinical staging (P<0.05), and CK5/6 was associated with molecular typing and histological grading (P<0.05). Spearman rank correlation analysis showed that the expressions of P120ctn, p53, and CK5/6 in cancer tissues were positively correlated with each other (r=0.384, 0.406, 0.581, allP<0.05). After 2 cycles of NAC for 120 patients before surgery, the effective rate was 63.33% (76/120). Univariate analysis showed that the effective rate was lower in patients with tumor diameter>2cm, histological grade G3, lymph node metastasis, P120ctn positive expression, p53 positive expression, and CK5/6 positive expression (P<0.05). Multivariate Logistic regression analysis revealed that lymph node metastasis, positive P120ctn expression, and positive p53 expression were risk factors affecting the efficacy of NAC in patients (P<0.05). Conclusion: The expressions of P120ctn, p53, and CK5/6 in cancer tissues of patients with IBC are significantly increased, and they are related to the clinicopathological characteristics of patients. The positive expressions of P120ctn and p53 are influencing factors for the efficacy of preoperative NAC.
林伟强, 袁惠玲, 温润耀, 叶建森, 张爱玲. 浸润性乳腺癌患者组织P120ctn p53及CK5/6表达及意义分析[J]. 河北医学, 2023, 29(2): 259-265.
LIN Weiqiang, YUAN Huiling, WEN Runyao, et al. Expressions and Significance of P120ctn, p53 and CK5/6 in Tissues of Patients with Invasive Breast Carcinoma. HeBei Med, 2023, 29(2): 259-265.
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2023, Vol. 29 
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