新活素联合瑞舒伐他汀钙治疗扩张型心肌病心力衰竭的疗效分析

doi:10.3969/j.issn.1006-6233.2023.01.031

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摘要 目的: 探究新活素联合瑞舒伐他汀钙治疗扩张型心肌病心力衰竭(HF)疗效及对心功能和血清可溶性肿瘤发生抑制蛋白-2(sST2)、重组人半乳糖凝集素3(Galectin-3)、N-脑钠肽前体(NT-pro BNP)水平的影响,为治疗该病症提供方法。方法: 选取2018年10月至2021年10月于成都市第三人民医院收治的122例扩张型心肌病HF患者为研究对象,使用excel利用公式f(x)=rand()产生随机数字,再利用排序功能进行随机分组,得出随机总表,将患者分为观察组(n=61)和对照组(n=61)。两组患者均进行标准基础治疗,对照组在标准基础治疗之外予以采用瑞舒伐他汀钙治疗,观察组在对照组基础上予以新活素。比较两组患者治疗7d后疗效差异,评估两组患者治疗前、治疗7d后心功能[左室射血分数(LVEF)、左室舒张末内径(LVEDD)、每搏排血量(SV)]、血清标志物(sST2、Galectin-3、NT-pro BNP)差异,分析两组患者治疗7d内不良反应发生率差异。结果: 治疗7d后,两组患者总体疗效存在差异,观察组患者治疗后总有效率为95.08%,高于对照组的83.61%(P<0.05);治疗7d后,两组患者LVEF、SV均较治疗前上升,LVEDD、sST2、Galectin-3、NT-pro BNP均较治疗前降低,且观察组上述6种指标治疗前后差值均高于对照组(P<0.05);治疗7d内,两组患者不良反应发生率差异均无统计学意义(P>0.05),两组患者均未出现严重不良反应事件。结论: 新活素联合瑞舒伐他汀钙治疗扩张型心肌病HF疗效显著,对心肌重塑及纤溶系统功能均有一定调控效果,安全性较好。

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关键词 ：新活素, 瑞舒伐他汀钙, 扩张型心肌病, 心力衰竭, 心功能

Abstract：Objective: To explore the efficacy of combination of lyophilized recombinant human brain natriuretic peptide (lrhBNP) and rosuvastatin calcium in treating heart failure (HF) in dilated cardiomyopathy and its influence on cardiac function and levels of serum soluble suppression of tumorigenicity-2 (sST2), recombinant human galectin-3 (Galectin-3) ) and N-pro-brain natriuretic peptide (NT-pro BNP), so as to provide a treatment for this disease. Methods: One hundred and twenty-two patients with dilated cardiomyopathy complicated with HF who were treated in the Third People' s Hospital of Chengdu between October 2018 and October 2021 were enrolled. Random numbers were generated in Microsoft excel using the formula f(x)=rand() and then randomised using the sorting function to produce a randomised summary table, dividing the patients into an observation group (n=61) and a control group (n=61). Both groups were treated with standard basic therapy, with the control group treated with Rosuvastatin calcium in addition to the standard basic therapy and the observation group treated with lrhBNP on top of the control group. The difference in efficacy between the two groups after 7d of treatment was compared, and the differences in cardiac function [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), stroke volume (SV)] and serum markers (sST2, Galectin-3, NT-pro BNP) were evaluated before treatment and after 7d of treatment. The incidence rates of adverse reactions were analyzed within 7d of treatment. Results: After 7 d of treatment, there was a difference in the overall efficacy between both groups, and the total effective rate of the observation group at 95.08% after treatment was higher than the control group at 83.61% (P<0.05). The LVEF and SV in the two groups were increased after 7 d of treatment compared with those before treatment while the LVEDD, sST2, Galectin-3 and NT-pro BNP were reduced compared to before treatment, and the differences of the above six indicators before and after treatment in observation group were higher compared with those in control group (P<0.05). The incidence rates of adverse reactions within 7 d of treatment showed no statistical differences between the two groups (P>0.05), and there were no serious adverse events in the two groups. Conclusion: LrhBNPcombined with rosuvastatin calcium has a significant efficacy in the treatment of HF in dilated cardiomyopathy, and it has a certain regulatory effect on myocardial remodeling and fibrinolytic system function, with good safety.

Key words： Lrh-BNP Rosuvastatin calcium Dilated cardiomyopathy Heart failure Cardiac function

基金资助:四川省卫生健康科研课题普及项目,(编号:19PJ168)

引用本文:

陈旖旎, 童琳, 邹艳, 廖慧, 李璐娜. 新活素联合瑞舒伐他汀钙治疗扩张型心肌病心力衰竭的疗效分析[J]. 河北医学, 2023, 29(1): 162-167.
CHEN Yini, TONG Lin, ZOU Yan, et al. Analysis of the Efficacy of Lrh-BNP Combined with Resulvastatin Calcium in the Treatment of Heart Failure in Dilated Cardiomyopathy. HeBei Med, 2023, 29(1): 162-167.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.01.031 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I1/162

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