Abstract：Objective: To investigate the effects of ultra-pulse CO2 fractional laser on skin characteristics scores and skin barrier function in patients with photoaging. Methods: A total of 183 patients with skin photoaging admitted to the hospital between July 2018 and July 2020 were selected as the research subjects.The patients were divided into ultra-pulse group (n=102) and Er:YAG laser group (n=81) according to the non-randomized and concurrently controlled method.The patients in the ultra-pulse group received ultra-pulse CO2 fractional laser treatment,and the Er:YAG laser group was given Er:YAG fractional laser treatment.After 6 months of treatment,the skin characteristics scores (VISIA skin image analysis),skin barrier function [transepidermal water loss (TEwL),skin surface pH value,water content of stratum corneum,skin grease content] and level of improvement [Global Aesthetic Improvement Scale (GAIS),Global Score for Photoaging (GSP)] were compared between the two groups before treatment and at 3 months after treatment.The occurrence of adverse reactions during 6 months of treatment and satisfaction self-rating score at 3 months after treatment were compared between the two groups. Results: Before treatment,there were no statistical differences in skin characteristics scores,skin barrier function and improvement level between the two groups.The differences of scores of skin spots,texture,pores,red matter,purple matter and ultraviolet spots,TEwL,skin surface pH value,water content of stratum corneum,skin grease content,GAIS score and GSP score before and after treatment were significantly higher in ultra-pulse group than those in Er:YAG laser group (all P<0.05).The total satisfaction of patients in ultra-pulse group was significantly higher compared to Er:YAG laser group (P<0.05).Within 6 months of treatment,the differences in the occurrence of adverse reactions (pain,erythema,scar hypertrophy,hyperpigmentation) were not statistically significant between the two groups (all P>0.05). Conclusion: Ultra-pulse CO2 fractional laser has a definite efficacy on skin photoaging,and it can effectively improve the skin status and repair the skin barrier,and has high clinical application value.
王欢欢, 严晓雪. 超脉冲CO2点阵激光对光老化患者皮肤特征评分及皮肤屏障功能的影响[J]. 河北医学, 2022, 28(7): 1199-1205.
WANG Huanhuan, YAN Xiaoxue. Effects of Ultra-Pulse CO2 Fractional Laser on Skin Characteristics Scores and Skin Barrier Function in Patients with Photoaging. HeBei Med, 2022, 28(7): 1199-1205.
2022, Vol. 28 
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