Abstract：Objective: To understand the incidence and factors affecting postprandial hypotension in OSAHS patients and to provide a basis for the prevention and treatment of PPH in OSAHS patients through measuring incidence of postprandial hypotension (PPH) in patients with and without obstructive sleep apnea-hypopnea syndrome (OSAHS). Method: Ninety-eight patients with OSAHS diagnosed by PSG were divided into mild,moderate and severe groups according to AHI.There were thirty-two cases in mild group,thirty-three cases in moderate group and thirty-three cases in severe group,and another thirty-three cases in control group exclud OSAHS.The general data of subjects were recorded,the differences between four groups,the incidence of PPH and the influencing factors of PPH were compared. Results: There was no significant difference in the incidence of total PPH among the four groups; the incidence of breakfast PPH in mild and moderate OSAHS group was not significantly different from the control group (P>0.05); the incidence of breakfast PPH in severe OSAHS group was statistically different from that in mild OSAHS and control group (P<0.05); there was no significant difference in the incidence of breakfast PPH between moderate and severe OSAHS group (P>0.05). AHI,hypertension and diabetes were risk factors for PPH. Conclusion: The incidence of PPH increased with the severity of hypoxia.Hypertension,diabetes and hypoxia may be risk factors for PPH.
[1] Karem JP.Definition of obstructive sleep apnea-hypopnea syndrome[J].Revista de la Facultad de Medicina,2017,65(1):9-10. [2] Takizawa T,Shibata M,et al.Possible involvement of hypotension in postprandial headache:a case series[J].Headache,2017,57(9):1443-1448. [3] 张亚楠;陈天磊;耿雪,等.住院高血压合并冠心病患者餐后低血压的临床观察[J].中华医学杂志,2018,98(33):2641-2644. [4] Torres G,Sanchez M,Barbe F.Relationship between OSA and hypertens ion[J].Chest,2015,148(3):824- 832. [5] 梁瑞玲,任寿安.阻塞性睡眠呼吸暂停合并高血压发病机制研究进展[J].中华高血压杂志,2018,26(3):288-291. [6] Montezano AC,Touyz RM.Molecular mechanisms of hypertension-reactive oxygen species and antioxidants:a basic science update for the clinician[J].Can Cardiol,2012,28(3):288-295. [7] 席小青,蔡金凤,柳达,等.餐后低血压危险因素的临床研究[J].临床心血管病杂志,2017,33(12):1210-1214. [8] Pamidi S,Tasali E.Obstructive sleep apnea and type 2 diabetes:is there a link[J].Front Neurol,2012,3(1):126. [9] Kendzerska T,Gershon AS,Hawker G,et al.Obstructive sleep apnea and incident diabetes.A historical cohort study[J].Am Respir Crit Care Med,2014,190(2):218–225. [10] 周潇莹,孙子林.餐后低血压及糖尿病对其发病机制和治疗的影响研究进展[J].中国全科医学杂志,2021,24(7):890-900. [11] 张洁,郭立新.餐后低血压与糖尿病[J].中华糖尿病杂志,2014,6(4):269-271. [12] Vloet LC,Mehagnoul-Schipper DJ,Hoefnagels WH,et al.The influence of low-,normal-,and high-carbohydrate meals on blood pressure in elderly patients with postprandial hypotension[J].Gerontol A Biol Sci Med Sci,2001,56(12):744-748.
2022, Vol. 28 
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