Abstract：Objective: To explore the correlation between platelet to lymphocyte ratio (PLR) and disease activity in patients with systemic lupus erythematosus(SLE)during the first episode and initial treatment. Methods: A total of 572 patients with first attack and initial treatment of SLE were enrolled as SLE group, and 572 healthy people during the same period were enrolled as healthy control group, according to SLE disease activity index 2000, SLE patients were divided into low activity group (SLEDAI ≤ 9 points, n=294) and high activity group (SLEDAI > 9 points, n=278), the PLR of the above groups were compared respectively, and spearman statistical analysis was performed to investigate the correlation between PLR and disease activity of SLE. Results: The PLR of SLE patients was significantly higher than that of healthy controls (P<0.05). In SLE patients, the PLR of the high activity group was significantly higher than that of the low activity group (P<0.05). PLR was positively correlated with SLEDAI score (r=0.291, P<0.05), Erythrocyte sedimentation rate(r=0.207, P<0.05), C-reactive protein (r=0.302, P<0.05), anti-ds-DNA antibody(r=0.098, P<0.05),24h urine protein (r=0.173, P<0.05), negatively correlated with complement C3(r=-0.257, P<0.05) and complement C4(r=-0.223, P<0.05). The area under the receiver operating characteristic curve of PLR for predicting the high activity of SLE is 0.639 (P<0.05). When the optimal critical value was 170, the sensitivity was 58.3% and the specificity was 65.6%. Conclusion: PLR can be used as one of the evaluation indicators for disease activity of SLE.
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2022, Vol. 28 
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