Abstract：Objective: To investigate the Plasma adrenocorticotropic hormone (ACTH) level and clinical significance of type 2 diabetes mellitus (T2DM) patients with obesity. Methods: 102 T2DM patients with obesity treated in our hospital from January 2019 to June 2021 were selected as the research object and classified as the obesity group. At the same time, 100 T2DM patients without obesity treated in our hospital in the same period were selected as the non-obesity group, and 95 healthy adults who underwent physical examination in our hospital in the same period were selected as the control group. Fasting blood glucose (FPG), fasting insulin (fins), triglycerides (TG), total cholesterol (TC), homeostasis model insulin resistance index (HOMA-IR), plasma ACTH level and bone mineral density (BMD) were compared among the three groups. Pearson correlation analysis and multiple linear regression were used to explore the correlation between plasma ACTH level and various indexes in T2DM patients with obesity. Results: BMI, FPG, FINS, HOMA-IR, TG, TC and ACTH in obese group were significantly higher than those in the other two groups, and BMD was significantly lower than those in the other two groups. BMI, FPG, FINS, HOMA-IR, TG, TC and ACTH in non-obese group were significantly higher than those in the control group, and BMD was significantly lower than that in the control group (P<0.05). Pearson correlation analysis showed that the plasma ACTH level in obese patients was significantly positively correlated with BMI, FPG, FINS, HOMA-IR, TG and TC, and negatively correlated with BMD (P<0.05). Multiple linear regressions showed that BMI, FPG, HOMA-IR and BMD were the independent influencing factors of plasma ACTH level in obese patients (P<0.05). Conclusion: The plasma ACTH level of T2DM patients with obesity significantly increased, which was related to the disorder of glucose and lipid metabolism and the decrease of bone mineral density.
2022, Vol. 28 
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