YAG激光对黄褐斑患者抗氧化功能皮肤美容效果及皮肤屏障功能的影响

doi:10.3969/j.issn.1006-6233.2022.05.017

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摘要 目的:研究大光斑低能量Nd:YAG激光治疗黄褐斑的效果及安全性。方法:选取我院2018年1月至2021年1月收治的黄褐斑患者125例。使用随机数字表法简单随机分为两组,其中观察组63例,对照组62例,对照组使用氢醌乳膏治疗,观察组在对照组基础上使用大光斑低能量Nd:YAG激光治疗,比较两组患者的疗效、抗氧化能力、皮肤美容效果以及皮肤屏障功能。结果:观察组患者接受治疗后的总有效率显著高于对照组(P<0.05);两组患者的丙二醛(MDA)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)在治疗前、后及治疗前后的差值差异均无统计学意义(P>0.05),与治疗前相比,治疗后两组患者的MDA显著降低(P<0.05),SOD和CAT显著升高(P<0.05);接受治疗后,两组患者的皮肤黑素指数(MI)和红斑指数(EI)均显著降低(P<0.05),观察组患者治疗前后MI和EI的差值显著高于对照组(P<0.05);接受治疗后两组患者的皮脂含量和角质层含水量显著降低(P<0.05)、经表皮水分流失值(TEWL)显著增高(P<0.05),两组皮脂含量、角质层含水量以及TEWL治疗前后差值差异均不显著(P>0.05)。结论:大光斑低能量Nd:YAG激光联合氢醌乳膏治疗黄褐斑的治疗效果和皮肤美容效果优于只使用氢醌乳膏治疗,且其安全性较好,不会损伤患者的抗氧化能力和皮肤屏障功能

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	严晓雪
	王欢欢

关键词 ：黄褐斑, 激光治疗, 抗氧化功能, 皮肤美容效果, 皮肤屏障功能

Abstract：Objective: To study the effect and safety of large spot and low-energy Nd:YAG laser in the treatment of chloasma. Methods: Totally 125 patients with chloasma admitted to the hospital were selected between January 2018 and January 2021, and randomly divide into observation group (63 cases) and control group (62 cases) using random number table method. Patients in the control group were treated with hydroquinone cream, and patients in the observation group were treated with large spot low-energy Nd:YAG laser based on the treatment of control group. Therapeutic effects, antioxidant capacity, cosmetic results and skin barrier function in the two groups were compared. Results: After treatment, the total response rate in the observation group was significantly higher than that in the control group (P<0.05). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in the two groups showed no statistically significant difference before and after treatment, and there was no statistically significant difference in the difference value of each indicator before and after treatment (P>0.05). After treatment, MDA was significantly reduced (P<0.05), while SOD and CAT were significantly increased in the two groups (P<0.05). After treatment, skin melanin index (MI) and erythema index (EI) were significantly reduced in the two groups (P<0.05). The difference values of MI and EI before and after treatment in observation group were significantly higher than those in the control group (P<0.05). After treatment, the sebum content and water content of stratum corneum were significantly reduced (P<0.05), while transepidermal water loss (TEWL) was significantly increased in the two groups (P<0.05). There was no significant difference between the two groups in the difference values of sebum content, water content of stratum corneum and TEWL before and after treatment (P>0.05). Conclusion: The large spot low energy Nd:YAG laser combined with hydroquinone cream has better therapeutic and cosmetic skin results than hydroquinone cream only treatment for melasma, and it is safer and does not damage the patient's antioxidant capacity and skin barrier function.

Key words： Chloasma Laser treatment Antioxidant function Cosmetic result Skin barrier function

基金资助:国家自然科学基金项目,(编号:8157101513)

通讯作者: 王欢欢

引用本文:

严晓雪, 王欢欢. YAG激光对黄褐斑患者抗氧化功能皮肤美容效果及皮肤屏障功能的影响[J]. 河北医学, 2022, 28(5): 779-783.
YAN Xiaoxue, WANG Huanhuan. Effects of YAG Laser on Antioxidant Function Cosmetic Result and Skin Barrier Function in Patients with Chloasma. HeBei Med, 2022, 28(5): 779-783.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.05.017 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I5/779

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