老年冠心病心力衰竭患者血清脑钠肽C反应蛋白与心肌损伤程度及心功能的相关性分析

doi:10.3969/j.issn.1006-6233.2022.05.013

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摘要 目的:分析老年冠心病心力衰竭患者血清脑钠肽(BNP),C反应蛋白(CRP)与心肌损伤程度及心功能的相关性。方法:选择2019年1月至2021年1月遂宁市中心医院收治的106例老年冠心病心力衰竭患者,检测血清BNP、心肌肌钙蛋白I(cTnI)、CRP水平并进行相关性分析。结果:冠心病心力衰竭患者血清BNP、CRP、cTnI水平分别为(578.09±46.17)g/mL、(7.07±1.85)mg/l、(0.050±0.011)ng/mL;相关性分析显示血清BNP、CRP水平与cTnI呈正相关(P<0.05);不同分级老年冠心病心力衰竭患者血清BNP、CRP水平差异有统计学意义(P<0.05);Ⅰ~Ⅱ级心力衰竭患者血清BNP、CRP均显著低于Ⅲ级、Ⅳ级(P<0.05);Ⅲ级心力衰竭患者血清BNP、CRP均显著低于Ⅳ级(P<0.05);血清BNP、cTnI、CRP水平与心功能分级呈正相关(P<0.001)。结论:血清BNP、CRP与老年冠心病心力衰竭患者心肌损伤程度及心功能显著相关。

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	杨丽萍
	马俊杰
	侯斌
	谭震

关键词 ：冠心病, 心力衰竭, 心肌损伤程度, 心功能, 血清脑钠肽, C反应蛋白, 心肌肌钙蛋白

Abstract：Objective: To analyze the correlation of serum brain natriuretic peptide (BNP), and C-reactive protein (CRP) with the severity of myocardial injury and cardiac function in elderly patients with coronary heart disease and heart failure. Methods: A total of 106 elderly patients with coronary heart disease and heart failure admitted to Suining Central Hospital were selected between January 2019 and January 2021. The levels of serum BNP, cardiac troponin I (cTnI) and CRP were detected, and correlation analysis was conducted. Results: Serum BNP, CRP and cTnI levels of the patients enrolled were (578.09±46.17) g/ml, (7.07±1.85) mg/l and (0.050±0.011) ng/ml. Correlation analysis showed that serum BNP and CRP levels were positively correlated with cTnI (P<0.05). There were statistically significant differences in serum BNP and CRP levels between patients with different grades of heart failure (P<0.05). Serum BNP and CRP levels of patients with gradeⅠ~Ⅱ heart failure were significantly lower than those of patients with grade Ⅲ and grade Ⅳ (P<0.05). Serum BNP and CRP levels of patients with grade Ⅲ heart failure were significantly lower than those of patients with grade IV (P<0.05). Serum BNP, cTnI and CRP levels were positively correlated with cardiac function classification (P<0.05). Conclusion:Serum BNP, cTnI and CRP levels are correlated with heart failure in elderly patients with coronary heart disease, when serum BNP, cTnI, and CRP levels are significantly increased, it is necessary to be alert to the aggravation of myocardial injury and the increase of cardiac function.

Key words： Coronary heart disease Heart failure Severity of myocardial damage Cardiac function Serum brain natriuretic peptide C-reactive protein Cardiac troponin

基金资助:四川省基层卫生事业发展研究中心项目,(编号:SWFZ20-Q-058)

通讯作者: 马俊杰

引用本文:

杨丽萍, 马俊杰, 侯斌, 谭震. 老年冠心病心力衰竭患者血清脑钠肽C反应蛋白与心肌损伤程度及心功能的相关性分析[J]. 河北医学, 2022, 28(5): 763-765.
YANG Liping, MA Junjie, HOU Bin, et al. Correlation of Serum BNP and CRP with the Severity of Myocardial Injury and Cardiac Function in Elderly Patients with Coronary Heart Disease and Heart Failure. HeBei Med, 2022, 28(5): 763-765.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.05.013 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I5/763

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