Abstract：Objective: To explore the relationship of mean platelet volume (MPV), C-reactive protein (CRP) and fibrinogen (FIB) with the severity and prognosis of acute pancreatitis (AP). Methods: This study retrospectively analyzed the data of 88 patients with AP admitted to the hospital between April 2017 and April 2021. According to the severity of the disease, the patients enrolled were divided into mild (MAP) group (n=40), moderate (MSAP) group (n=38), and severe (SAP) group (n=10). The MPV, CRP and FIB levels in the 3 groups on admission were comparatively analyzed. The correlation of MPV, CRP and FIB with the Acute Physiologic and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, Ranson score and Bedside Index of Severity in Acute Pancreatitis (BISAP) score was analyzed. The ROC curve was plotted to evaluate the clinical prognostic value of MPV, CRP and FIB on admission, and their joint detection in AP. Results: The MPV and CRP level decreased in order from SAP group, MSAP group to MAP group (P<0.05). The MSAP group and the SAP group had higher FIB levels than the MAP group (P<0.05). However, there was no significant difference in FIB level between the MSAP group and the SAP group (P>0.05). MPV, CRP and FIB levels on admission were positively correlated with APACHE Ⅱ score, Ranson score and BISAP score (P<0.05). MPV, CRP and FIB on admission were of high prognostic value in AP (AUC=0.658, 0.668, 0.725), and their cut-off values were 12.31 fL, 84.265 mg/L, and 5.21 g/L. The area under the curve (AUC) value and sensitivity of combination of MPV, CRP and FIB3 for the prognosis of AP were significantly higher than those of MPV, CRP or FIB.Conclusion: Serum MPV, CRP and FIB are positively correlated with the severity of AP. Combination of the three can improve the prognosis of AP, which is conducive to guiding the treatment of AP.
邓中波, 叶淳娟, 徐玉龙. 血清血小板平均体积 CRP 纤维蛋白原与急性胰腺炎患者病情程度和预后转归的关系分析[J]. 河北医学, 2022, 28(4): 670-674.
DENG Zhongbo, YE Chunjuan, Xu Yulong. Analysis of the Relationship of Mean Platelet Volume C-Reactive Protein and Fibrinogen with the Severity and Prognosis of Acute Pancreatitis. HeBei Med, 2022, 28(4): 670-674.
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2022, Vol. 28 
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