腋窝淋巴结转移的三阴性乳腺癌组织中C-erbB-2 NuSAP1表达及意义分析

doi:10.3969/j.issn.1006-6233.2022.02.011

摘要
图/表
参考文献
相关文章 (9)

全文: PDF (1237 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 观察乳腺癌中表皮生长因子受体2(C-erbB-2)和核仁纺锤体相关蛋白1(NuSAP1)在发生腋窝淋巴结转移的三阴性乳腺癌患者肿瘤组织和癌旁组织的表达情况并分析其意义。方法: 回顾性选取2016年7月至2020年10月于本院治疗的150例乳腺癌患者的临床资料,依据免疫组化情况将其分为观察组(三阴性乳腺癌)和对照组(非三阴性乳腺癌),观察组患者49例,对照组患者101例。比较两组C-erbB-2和NuSAP1表达水平并分析其与腋窝淋巴结转移情况。结果: 观察组C-erbB-2阳性高表达率为87.76%,明显高于对照组63.37%(P<0.05);观察组NuSAP1阳性高表达率为79.59%,明显高于对照组61.39%(P<0.05);49例三阴性乳腺癌患者中,未出现腋窝淋巴结转移者22例,出现腋窝淋巴结转移者27例。C-erbB-2和NuSAP1高表达组腋窝淋巴结转移率明显高于低表达组(P<0.05)。结论: C-erbB-2和NuSAP1在三阴性乳腺中阳性高表达率要高于非三阴性乳腺癌,且在发生腋窝淋巴结转移中的阳性高表达率又明显高于未发生腋窝淋巴结转移者,有望成为新的预后指标。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：淋巴结转移, 三阴性乳腺癌, 表皮生长因子受体2, 核仁纺锤体相关蛋白1

Abstract：Objective: To investigate the expression of epidermal growth factor receptor 2 (C-erbB-2) and nuclear spindle associated protein 1 (NuSAP1) in tumor tissues and paracancer tissues of triple negative breast cancer patients with axillary lymph node metastasis and to analyze their significance. Methods: Clinical data of 150 breast cancer patients treated in our hospital from July 2016 to October 2020 were retrospectively selected, and the patients were divided into observation group (triple negative breast cancer) and control group (non triple negative breast cancer) according to immunohistochemistry, with 49 cases in observation group and 101 cases in control group. The expression levels of C-erbB-2 and NuSAP1 were compared between the two groups, and their relationship with axillary lymph node metastasis was analyzed. Results: The high expression rate of C-erbB-2 in observation group was 87.76%, which was significantly higher than that in control group (63.37%) (P<0.05). The positive high expression rate of NuSAP1 in observation group was 79.59%, which was significantly higher than that in control group (61.39%) (P<0.05). Among the 49 patients with triple negative breast cancer, 22 had no axillary lymph node metastasis and 27 had axillary lymph node metastasis. The axillary lymph node metastasis rate of c-erbB-2 and NuSAP1 high expression group was significantly higher than that of low expression group (P<0.05). Conclusion: The positive overexpression rate of C-erbB-2 and NuSAP1 in triple negative breast cancer is higher than that in non triple negative breast cancer, and the positive overexpression rate of C-erbB-2 and NuSAP1 in axillary lymph node metastasis is significantly higher than that in non-axillary lymph node metastasis, which may be a new prognostic indicator.

Key words： Lymph node metastasis Triple negative breast cancer Epidermal growth factor receptor 2 Nucleolar spindle associated protein 1

基金资助:陕西省重点研发计划项目,(编号:2021SF-010)

通讯作者: 印玉龙

引用本文:

刘向华, 吕勇刚, 孟庆杰, 韩晓刚, 张浩萌, 印玉龙. 腋窝淋巴结转移的三阴性乳腺癌组织中C-erbB-2 NuSAP1表达及意义分析[J]. 河北医学, 2022, 28(2): 236-240.
LIU Xianghua, LV Yonggang, MENG Qingjie, et al. Expression and Significance of C-erbB-2 and NuSAP1 in Triple Negative Breast Cancer with Axillary Lymph Node Metastasis. HeBei Med, 2022, 28(2): 236-240.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.02.011 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I2/236

[1] 李贺,郑荣寿,张思维,等.2014年中国女性乳腺癌发病与死亡分析[J].中华肿瘤杂志,2018,40(3):166~171.
[2] 范东伟,姚昌洋,姚廷敬.三阴性乳腺癌的研究进展[J].医学综述,2018,24(1):77~81.
[3] 刘蕾,张瑾.三阴性乳腺癌靶向治疗研究进展[J].天津医药,2018,46(12):1363~1367.
[4] 王阿军,章斌.乳腺癌超声特征与分子分型相关性研究进展[J].中国血液流变学杂志,2018,28(1):112~115.
[5] 王金文,文秋元,李弘夏,等.核仁纺锤体相关蛋白在恶性肿瘤中作用的研究进展[J].临床与实验病理学杂志,2019,35(12):64~67.
[6] 李甜,周钱梅,张卫红.PI3K/Akt/mTOR信号通路在三阴性乳腺癌治疗中的研究进展[J].中国肿瘤,2018,27(1):40~45.
[7] 孙晓萌,高社干.三阴性乳腺癌的临床治疗现状及新进展[J].实用癌症杂志,2020,219(6):171~173.
[8] 徐兵河,王树森,江泽飞,等.中国晚期乳腺癌维持治疗专家共识[J].中华普通外科学文献(电子版),2018,12(1):7~11.
[9] 蒋梦怡,陆言巧,王红霞.乳腺癌异质性的研究进展及临床意义[J].中国癌症杂志,2020,247(5):79~85.
[10] 徐平,杨敏,刘勇,等.C-erbB-2和Ki-67表达阳性及阴性的乳腺癌超声造影定性及定量参数对比观察[J].山东医药,2020,60(30):57~59.
[11] 闫佩毅,袁亚,张骥,等.乳腺癌C-erbB-2基因启动子区CpG岛的甲基化状态与雄激素受体表达的相关性分析[J].检验医学,2018,33(6):89~95.
[12] 靳凤梅,王惠,马苏美,等.乳腺癌ABVS表现与ER、PR、Her-2及Ki67的相关性研究[J].中国超声医学杂志,2018,328(2):115~119.
[13] 张顺礼,王雅琪,胡继卫,等.乳腺癌组织中核仁纺缍体相关蛋白1表达与腋窝淋巴结转移的关系[J].肿瘤学杂志,2020,218(11):33~37.
[14] Liu Z,Guan C,Lu C,et al.High NUSAP1 expression predicts poor prognosis in colon cancer[J].Pathol Res Pract,2018,214(7):968~973.
[15] Xu Z,Wang Y,Xiong J,et al.NUSAP1 knockdown inhibits cell growth and metastasis of non-small-cell lung cancer through regulating BTG2/PI3K/Akt signaling[J].Cell Physiol,2020,235(4):3886~3893.