摘要目的: 探讨两种不同手术方式对老年膝关节骨性关节炎患者功能恢复及血清IL-1、IL-17、ESR水平的影响。方法: 回顾性分析2018年1月到2020年12月本院关节外科收治的153例老年膝关节骨性关节炎(knee Osteoarthritis,KOA)患者,按照手术方式不同将其分为单髁置换组和全膝关节置换组,单髁置换组76例,全膝关节置换组77例。比较两组患者的手术时间、住院时间、住院费用、白细胞介素-1(Interleukin-1,IL-1)、白细胞介素-17(Interleukin-17,IL-17)、红细胞沉降率(Erythrocyte Sedimentation Rate,ESR)、膝关节功能评分(knee society score,KSS)、美国特种外科医院评分(Hospital for special surgery,HSS)、Lysholm膝关节评分和并发症发生情况。结果: 单髁置换组手术时间、住院时间少于全膝关节置换组(P<0.05),两组住院费用无统计学差异(P>0.05);两组患者术前IL-1、IL-17、ESR无统计学差异(P>0.05),术后两组患者血清IL-1、IL-17水平均较术前下降(P<0.01),ESR与术前相比无统计学意义(P>0.05),两组差值无统计学意义(P>0.05);两组患者术前KSS评分、HSS评分、Lysholm膝关节评分无统计学差异(P>0.05),术后两组患者KSS评分、HSS评分、Lysholm膝关节评分较术前均上升(P<0.01),两组差值无统计学意义(P>0.05);单髁置换组并发症显著低于全膝关节置换组(P<0.05)。结论: 单髁置换术手术时间短、住院时间短、伤口恢复快,并发症少,临床值得优先推荐。
Abstract：Objective: To investigate the effect of two different surgical methods on functional recovery and serum IL-1, IL-17 and ESR in elderly patients with knee osteoarthritis (KOA). Methods: This study retrospectively reviewed 153 elderly patients with KOA admitted to the department of joint surgery in the hospital between January 2018 and December 2020. The patients were divided into unicompartmental knee arthroplasty group (n=76) and total knee arthroplasty group (n=77) according to the surgical method. The operation time, length of hospital stay, hospitalization expenses, interleukin-1 (IL-1), interleukin-17 (IL-17), erythrocyte sedimentation rate (ESR), knee society score (KSS), Hospital for Special Surgery (HSS) score, Lysholm knee score, and complications were compared between the two groups. Results: The operation time and hospital stay of the unicompartmental knee arthroplasty group were significantly shorter than those of the total knee arthroplasty group (P<0.05), but there was no statistical difference in hospitalization expenses between the two groups (P>0.05). There was no significant difference in IL-1, IL-17 and ESR between the two groups before surgery (P>0.05). After surgery, the levels of serum IL-1 and IL-17 were reduced in the two groups (P<0.01), but no significant change in ESR was found (P>0.05), without statistically significant difference between the two groups (P>0.05). There was no statistically significant difference in KSS score, HSS score and Lysholm knee score between the two groups before surgery (P>0.05). After surgery, the above scores of the two groups were increased (P<0.01), but there was no statistically significant difference between the two groups (P>0.05). The incidence of complications in the unicompartmental knee arthroplasty group was significantly lower than that in the total knee arthroplasty group (P<0.05). Conclusion: Unicompartmental knee arthroplasty has the advantages of short duration, short hospital stay, quick wound healing, and few complications.
杨辉. 两种不同手术方式治疗对老年膝关节骨性关节炎患者功能恢复及血清IL-1 IL-17 ESR水平的影响[J]. 河北医学, 2021, 27(12): 2061-2064.
YANG Hui. Effect of Two Different Surgical Methods on Functional Recovery and Serum IL-1 IL-17 and ESR in Elderly Patients with Knee Osteoarthritis. HeBei Med, 2021, 27(12): 2061-2064.
2021, Vol. 27 
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