Abstract：Objective: To study the correlation between serum homocysteine (Hcy), procalcitonin (PCT), hematocrit (HCT) levels and severity of intestinal mucosal injury in patients with severe acute pancreatitis (SAP). Methods: A total of 152 patients (SAP group) with SAP treated in the hospital were enrolled for retrospective analysis between March 2018 and April 2021. According to presence or absence of intestinal mucosal injury, they were divided into injury group (110 cases) and non-injury group (42 cases). Other 92 healthy volunteers undergoing physical examination during the same period were enrolled as control group. The levels of serum Hcy, PCT and HCT were detected and compared among all groups. The predictive value of the above indexes for intestinal mucosal injury, and their relationship with severity of intestinal mucosal injury were analyzed. Results: The levels of serum Hcy, PCT and HCT in SAP group were significantly higher than those in control group, which were significantly higher in injury group than in non-injury group (P<0.05). AUC value and sensitivity of serum Hcy combined with PCT and HCT for predicting intestinal mucosal injury were significantly higher than those of single index (P<0.05). With the aggravation of intestinal mucosal injury, levels of serum Hcy, PCT and HCT were gradually increased (P<0.05). The levels of serum Hcy, PCT and HCT were positively correlated with the severity of intestinal mucosal injury in SAP patients (P<0.05). Conclusion: There are abnormal changes in serum Hcy, PCT and HCT levels in SAP patients. The detection of the above indexes is not only conducive to predicting the occurrence of intestinal mucosal injury, but also can better reflect the severity of intestinal mucosal injury.
赵冰, 刘巍, 刘丹. 重症急性胰腺炎患者血清Hcy PCT HCT水平与肠道黏膜损伤程度的相关性分析[J]. 河北医学, 2021, 27(12): 1983-1986.
ZHAO Bing, LIU Wei, LIU Dan. Correlation Between Serum Hcy, PCT, HCT Levels and Severity of Intestinal Mucosal Injury in Patients with Severe Acute Pancreatitis. HeBei Med, 2021, 27(12): 1983-1986.
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2021, Vol. 27 
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