摘要目的: 探究心房颤动患者血清总胆汁酸(total bile acid,TBA)、超敏C反应蛋白(hypersensitive C reactive protein,hs-CRP)、血浆脑钠肽(Brain Natriuretic Peptide,BNP)水平变化及与心率变异性(heart rate variability,HRV)的相关性分析。方法: 应用回顾性方法选择并分析2017年3月至2019年6月来本院心内科就诊的217例心房颤动患者作为研究对象,并另选100名同期体检健康患者作为对照组,两组患者均进行24h心电监护,检测并比较两组患者的血清TBA、hs-CRP、BNP水平及HRV[24h所有窦性心搏间期NN标准差(NN standard deviation,SDNN);全程相邻NN间期差值的均方根(RMS of NN interval difference,RMSSD);全程记录中每5minNN间期平均值的标准差(NN standard deviation of mean of interval,SDANN);超过50ms的个数占总窦性心搏数的百分率(As a percentage of total sinusoids,the number of ms over 50,PNN50)]。结果: 比较结果显示,研究组的TBA、hs-CRP、BNP高于对照组,SDNN、RMSSD、SDANN、PNN50低于对照组,差异有统计学意义(P<0.05);相关性分析结果显示,TBA与SDNN、RMSSD、SDANN、PNN50呈正相(r=0.469、0.474、0.447、0.418,P<0.05);hs-CRP与SDNN、RMSSD、SDANN、PNN50呈正相(r=0.560、0.595、0.600、0.582,P<0.05);BNP与SDNN、RMSSD、SDANN、PNN50呈正相(r=0.566、0.634、0.624、0.598,P<0.05)。结论: 心房颤动患者血清TBA、hs-CRP、BNP水平均上升,且血清TBA、hs-CRP、BNP水平与HRV呈正相关。
Abstract：Objective: To investigate the changes of serum total bile acid (total bile acid,TBA), hypersensitive C reactive protein (hypersensitive C reactive protein,hs-CRP), plasma brain natriuretic peptide (Brain Natriuretic Peptide,BNP) levels and their correlation with heart rate variability (heart rate variability,HRV) in patients with atrial fibrillation. Methods: To select and analyze 217 patients with atrial fibrillation admitted to our department from March 2017 to June 2019, and another 100 healthy controls were selected as control group. Both groups underwent 24 h ECG monitoring. The serum TBA, hs-CRP, BNP levels and the standard deviation (NN standard deviation,) HRV [24h all sinus rhythm intervals], RMSSD were measured and compared. NN standard deviation of mean of interval of mean per 5 mins and PNN50 were recorded. Results: The comparison shows that TBA, hs-CRP, BNP in the study group were higher than in the control group, SDNN, RMSSD, SDANN, PNN50 lower than the control group; the difference was statistically significant (P<0.05). Correlation analysis showed that TBA and SDNN, RMSSD, SDANN, PNN50 are positive (r=0.469,0.474,0.447,0.418, P<0.05); hs-CRP is in positive phase with SDNN, RMSSD, SDANN, PNN50 (r=0.560,0.595,0.600,0.582, P<0.05); BNP and SDNN, RMSSD, SDANN, PNN50 were positive (r=0.566,0.634,0.624,0.598, P<0.05). Conclusion: Serum TBA, hs-CRP, BNP levels increased in patients with atrial fibrillation, and serum TBA, hs-CRP, BNP levels were positively correlated with HRV.
李朋, 徐建辉, 胡威. 心房颤动患者血清总胆汁酸 hs-CRP BNP水平变化及与心率变异性的相关性分析[J]. 河北医学, 2021, 27(9): 1432-1435.
LI Peng, XU Jianhui, HU Wei. Changes of Serum Total Bile Acids and Hs-CRP BNP Levels in Patients with Atrial Fibrillation and Their Correlation with Heart Rate Variability. HeBei Med, 2021, 27(9): 1432-1435.
2021, Vol. 27 
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