Abstract：Objective: To analyze the influence of MMP-9 and sFlt-1 on menstrual cycle in patients with endometriosis. Methods: 113 patients with endometriosis admitted to our hospital from March 2017 to March 2020 were included in this study. Another 62 healthy women who came to our hospital for physical examination in the same period were selected as the control group. The levels of MMP-9 and sFlt-1 in peripheral blood were detected by ELISA. The levels of MMP-9 and sFlt-1 in peripheral blood of patients with different menstrual cycles, different R-AFS stages and endometriosis were compared between the two groups, and the correlation between the levels of MMP-9 and sFlt-1 in peripheral blood and R-AFS stages and menstrual cycle was analyzed. Results: The levels of MMP-9 and sFlt-1 in peripheral blood of endometriosis group were significantly higher than those of control group in proliferative phase and secretory phase, and the levels of sFlt-1 in peripheral blood of endometriosis group were significantly lower than those of control group. The differences were statistically significant (P<0.05), but the levels of MMP-9 and sFlt-1 in peripheral blood of endometriosis group and control group had no significant changes in proliferative phase and secretory phase, and the differences were not statistically significant (P>0.05). The level of MMP-9 in peripheral blood of patients with endometriosis increased with the increase of R-AFS stage, and the level of sFlt-1 in peripheral blood decreased with the increase of R-AFS stage (P<0.05). There was a negative correlation between MMP-9 and sFlt-1 (P<0.05), a positive correlation between MMP-9 and R-AFS stage (P<0.05), and a negative correlation between sFlt-1 and R-AFS stage (P<0.05), but there was no correlation between MMP-9 and sFlt-1 and menstrual cycle (P>0.05). Conclusion: The levels of MMP-9 and sFlt-1 in peripheral blood of patients with endometriosis are significantly higher than those of patients with endometriosis. The levels of MMP-9 and sFlt-1 are significantly correlated with the progress of endometriosis, but not with the menstrual cycle.
汪佳, 沙敏, 葛红山, 张萍, 朱丹丹, 钱华. 外周血MMP-9和sFlt-1水平对子宫内膜异位症患者月经周期的影响[J]. 河北医学, 2021, 27(8): 1275-1279.
WANG Jia, SHA Min, GE Hongshan, et al. Effect of MMP-9 and sFlt-1 in Peripheral Blood on Menstrual Cycle in Patients with Endometriosis. HeBei Med, 2021, 27(8): 1275-1279.
[1] An,Chaljub E,Medlock D.Endometriosis[J].JAMA,2018,320(24): 2608. [2] Fung JN,Montgomery GW.Genetics of endometriosis: State of the art on genetic risk factors for endometriosis[J].Best Pract Res Clin Obstet Gynaecol,2018,50(2):61~71. [3] Nanda A,T K,Banerjee P,et al.Cytokines,angiogenesis,and extracellular matrix degradation are augmented by oxidative stress in endometriosis[J].Ann Lab Med,2020,40(5): 390~397. [4] Kodarahmian M,Amidi F,Moini A,et al.The modulating effects of resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial[J].Gynecol Endocrinol,2019,35(8):719~726. [5] Figueira SF,Wolf C,D'innocenzo MA,et al.Economic evaluation of sFlt-1/PlGF ratio test in pre-eclampsia prediction and diagnosis in two Brazilian hospitals[J].Pregnancy Hypertens,2018,13(9):30~36. [6] 郎景和,崔恒,戴毅,等.2015年子宫内膜异位症的诊治指南专家解读[J].中华妇产科杂志,2017,52(12):857~861. [7] Chapron C,Marcellin L,Borghese B,et al.Rethinking mechanisms,diagnosis and management of endometriosis[J].Nat Rev Endocrinol,2019,15(11):666~682. [8] Lin X,Dai Y,Xu W,et al.Hypoxia promotes ectopic adhesion ability of endometrial stromal cells via TGF-β1/Smad signaling in endometriosis[J].Endocrinology,2018,159(4):1630~1641. [9] Batkowiec M,Maksym RB,Wlodarski PK.The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis[J].Mol Med Rep,2018,18(3):3123~3136. [10] Guo F,Liu J,Han X,et al.FBXO22 suppresses metastasis in human renal cell carcinoma via inhibiting MMP-9-Mediated migration and invasion and VEGF-Mediated angiogenesis[J].Int Biol Sci,2019,15(3):647~656. [11] 许丽娜,赵静,应仙华.子宫内膜异位症患者血清syndecan-1及MMP-9水平变化及其临床意义[J].中华内分泌外科杂志,2018,12(4):326~329. [12] Kim BS,Yang SS,You HK,et al.Fucoidan-induced osteogenic differentiation promotes angiogenesis by inducing vascular endothelial growth factor secretion and accelerates bone repair[J].Tissue Eng Regen Med,2018,12(3):e1311~e1324. [13] Rashidi BH,Sarhangi N,Aminimoghaddam S,et al.Association of vascular endothelial growth factor (VEGF) Gene polymorphisms and expression with the risk of endometriosis: a case-control study[J].Mol Biol Rep,2019,46(3):3445~3450. [14] Wong Chuen Cesar Sze,Cheung MT,Yin Lewis Lai Luk,et al.Prognostic significance of cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients[J].Oncotarget,2018,9(6):6737~6751. [15] Uzun M,Gencer M,Turkon H,et al.Effects of melatonin on blood pressure,oxidative stress and placental expressions of TNFα,IL-6,VEGF and sFlt-1 in RUPP rat model of preeclampsia[J].Arch Med Res,2017,48(7):592~598.
2021, Vol. 27 
冀公网安备13080202000677号