Abstract：Objective: To explore the relationship between serum vitamin D (VITD) and airway hyperresponsiveness and respiratory mechanical parameters in children with bronchial asthma (BA), as well as its influence on the therapeutic effect. Methods: A total of 113 children with BA from March 2018 to August 2020 in our hospital were selected as the study group, and another 113 children for healthy physical examination during the same period were selected as the control group. The serum VitD levels of the two groups were compared. According to the serum VitD levels, the study group was divided into normal VitD children (n=35) and VitD deficient children (n=78). Clinical data, airway hyperresponsiveness [minimum induced cumulative dose (Dmin) by bronchial stimulation test (Astograph), serum total immunoglobulin E (IgE)], respiratory mechanical parameters [intraairway pressure (PAW), respiratory viscosity resistance (R), total static compliance (CST), platform pressure (PLAT)] of the children with normal and deficient VitD in the study group were compared. The correlation between serum VitD and airway hyperresponsiveness and respiratory mechanical parameters was analyzed. All the study groups were given routine treatment. The treatment effect of children with normal and deficient VitD in the study group was compared, and the influence of serum VitD level on the treatment effect of children with BA was analyzed. Results: The level of serum VitD in the study group was lower than that in the control group (P<0.05). In the study group, Dmin and CST of children with VITD deficiency were lower than those with normal VITD, and serum total IgE, PAW, R and Plat were higher than those with normal VITD (P<0.05). Serum VitD was positively correlated with Dmin and CST, and negatively correlated with serum total IgE, PAW, R and Plat (P<0.05). In the study group, the total effective rate of patients with normal VITD was higher than that of patients with VITD deficiency (P<0.05). There was a significant correlation between serum VitD and BA (P<0.05). Conclusions: The serum VITD in BA children is significantly reduced, which is closely related to airway hyperresponsiveness and respiratory mechanical parameters. Supplementation of VITD can help improve the therapeutic effect, which is of great significance in clinical diagnosis and treatment.
邱萌. 支气管哮喘患儿血清维生素D与气道 呼吸参数关系及对预后的影响[J]. 河北医学, 2021, 27(8): 1339-1343.
QIU Meng. Relationship Between Serum Vitamin D and Airway and Respiratory Parameters in Children with Bronchial Asthma and Its Influence on Prognosis. HeBei Med, 2021, 27(8): 1339-1343.
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2021, Vol. 27 
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