An Investigation of the Effect of High-Flow Humidified Oxygen Therapy on the Clinical Efficacy and the Expression of IL-8 and IL-6 in Elderly Patients with Pneumonia
WANG Guoyu, QU Zhonghui, LI Wei, et al
The Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China
Abstract：Objective: To investigate the effect of high-flow humidified oxygen therapy on the clinical efficacy and the expression of IL-8 and IL-6 in elderly patients with pneumonia. Methods: 80 elderly patients with pneumonia admitted to our hospital from January 2017 to August 2019 were randomly divided into two groups, 40 cases in each group. Both groups were administered antitussive, expectorant, anti-inflammatory and other treatment measures. 40 patients of the control group were given traditional artificial airway humidification method, while 40 patients of the study group were given high flow humidified oxygen therapy.The clinical symptoms, heart rate, suction frequency, SPO2, serum IL-6 and serum IL-8 levels of the two groups were observed and compared before and after treatment. Results: Before treatment, there were no significant difference in serum IL-6 and IL-8 between the two groups (P>0.05). After clinical application of high-flow humidified oxygen therapy, Hypothermic time, time of change of character and viscosity from sputum, decreased or disappearance time of lung rales in the study group were significantly shorter than those of the control group; heart rate and aspiration frequency were lower and SPO2 was higher than those of the control group(P<0.05). The decrease of serum IL-6 and IL-8 in the study group were significantly lower than those in the control group. (P<0.05). Conclusion: Application of high flow humidified oxygen therapy can significantly improve the clinical efficacy, increase oxygenation, reduce the expression of inflammatory factors IL-6,IL-8.
王国玉, 曲忠慧, 李伟, 巴春贺, 王璐, 王浩宇. 探讨高流量湿化氧疗对老年肺炎患者临床疗效及炎症因子IL-8 IL-6的影响[J]. 河北医学, 2021, 27(8): 1321-1325.
WANG Guoyu, QU Zhonghui, LI Wei, et al. An Investigation of the Effect of High-Flow Humidified Oxygen Therapy on the Clinical Efficacy and the Expression of IL-8 and IL-6 in Elderly Patients with Pneumonia. HeBei Med, 2021, 27(8): 1321-1325.
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2021, Vol. 27 
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