Abstract：Objective: To study the predictive value of antithrombin-III (AT-Ⅲ) coagulation index and D-dimer (D-D) in different degrees of pregnancy-induced hypertension. Methods: A total of 108 patients with pregnancy-induced hypertension admitted to our hospital from December 2017 to December 2019 were retrospectively analyzed. They were sub-grouped as pregnancy-induced hypertension group(42 cases), mild PE group (36 cases) and severe PE group (30cases) according to the severity of the disease. Another selection of normal pregnancy women during the same period were made the normal group (48 cases). The differences of four coagulation, AT-Ⅲ and D-D between each group were compared, and the correlation between each index and disease severity was analyzed. The working characteristic curve (ROC curve) was used to analyze the predictive value of the above indexes on the severity of the disease. Results: PT、APTT、TT and AT-Ⅲ levels of normal group> pregnancy-induced hypertension grouP> mild PE group and severe PE group, the values were statistically significant (Pall<0.05);The FIB、D-D level of normal grouP< pregnancy-induced hypertension grouP< mild PE group and severe PE group, the values were statistically significant (Pall<0.05).Spearman correlation analysis shows that PT, APTT, TT, and the AT-Ⅲ were significant negative correlated with PE (r= -0.790, -0.680,- 0.826, -0.597, Pall<0.05), FIB and D-D were positively correlated with PE (r =0.690, 0.780, Pall<0.05).ROC curve analysis showed that PT, APTT, TT, FIB, the AT-Ⅲ and D-D to predict severe PE AUC were 0.934, 0.930, 0.912, 0.874, 0.805, 0.867, predictive value is better . Conclusion: The coagulation condition of patients with different degrees of pregnancy-induced hypertension can be better reflected by four coagulations, AT-Ⅲ and D-D, and the predictive value of severe PE is high. By monitoring the above indexes, the severity of the disease can be detected as soon as possible, and the symptomatic treatment can be given.
蔡聪颖. 抗凝血酶原-Ⅲ 凝血指标和D-二聚体对不同程度妊娠高血压疾病的诊断价值[J]. 河北医学, 2021, 27(6): 920-923.
CAI Congying. Diagnostic Value of Antithrombin-III Coagulation Index and D-Dimer in Different Degrees of Pregnancy-Induced Hypertension. HeBei Med, 2021, 27(6): 920-923.
2021, Vol. 27 
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