Effect of Combined Antihypertensive Regimen on Cardiac Function, Hemodynamics Peripheral Blood Hcy and CRP Levels in Patients with Old Myocardial Infarction and Heart Failure
XIN Guoyong, ZHENG Gaomei, ZHANG Huihui
Fuyang People's Hospital, Anhui Fuyang 236000, China
Abstract：Objective:To explore the effect of combined antihypertensive regimen on cardiac function, hemodynamics, peripheral blood Hcy and CRP levels in the treatment old myocardial infarction combined with heart failure. Methods:A retrospective analysis was conducted with the clinical data of 60 patients with old myocardial infarction and heart failure admitted to our hospital from January 2019 to March 2020 who were divided into groups A, B, and C according to their treatment methods. 22 patients in group A were treated with valerian Sartan combined with benazepril hydrochloride treatment, 20 patients in group B were treated with valsartan alone, and 18 patients in group C were treated with benazepril hydrochloride alone. The blood pressure status and cardiac function indexes of the three groups before and after treatment were compared. Left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV), hemodynamic indicators Stroke volume (SV), cardiac output (CO) and cardiac index (CI), peripheral blood homocysteine (Hcy), C-reactive protein (CRP) difference and clinical efficacy. Results:①After treatment, the systolic and diastolic blood pressure of group A were significantly lower than those of group B and C, P<0.05; ②After treatment, the LVEF level of group A was higher than that of group B and C, and the levels of LVESV and LVEDV were lower than group B and C; The difference between the LVESV and LVEDV groups was statistically significant, P<0.05; ③After treatment, the three indexes of group A were higher than those in groups B and C, P<0.05; ④After treatment, the levels of Hcy and CRP in group A were significantly lower than in groups B and C, P<0.05; ⑤The total effective rate of patients in group A was 95.45%, which was significantly higher than 80.00% in group B and 77.78% in group C. Conclusion: The combined antihypertensive regimen is effective in treating patients with old myocardial infarction combined with heart failure, which can improve the patient's cardiac contractility, regulate hemodynamic indicators, and reduce Hcy and CRP levels.
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2021, Vol. 27 
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